日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Camonsertib, an ATRi, in Combination with Low-Dose Gemcitabine in Solid Tumors with DNA Damage Response Aberrations: Preclinical and Phase Ib Results

Camonsertib(一种ATRi)联合低剂量吉西他滨治疗伴有DNA损伤反应异常的实体瘤:临床前和Ib期研究结果

Rosen, Ezra Y; Yap, Timothy A; Fontana, Elisa; Lee, Elizabeth K; Mahalingam, Devalingam; Højgaard, Martin; Mettu, Niharika B; Cote, Gregory M; Plummer, Ruth; Koehler, Maria; Ulanet, Danielle; Fei, Kezhen; Silverman, Ian M; Schonhoft, Joseph D; Rimkunas, Victoria; Bacque, Emeline S; Gomez, Gabriela; Fretland, Adrian J; Roulston, Anne; Li, Li; Baruah, Prasamit; Zimmermann, Michal; Yang, Julia; Carneiro, Benedito A; Lheureux, Stephanie

The cold immunological landscape of ATM-deficient cancers.

ATM缺陷型癌症的冷漠免疫学特征

Sinha Sonali, Ng Victor, Novaj Ardijana, Zhu Yingjei, Yazaki Shu, Pei Xin, Derakhshan Fatemeh, Pareja Fresia, Setton Jeremy, Naulin Flavie, Beltrán-Visiedo Manuel, Shin Ethan, Longhini Ana Leda F, Gardner Rui, Ma Jennifer, Ma Kevin, Roulston Anne, Morris Stephen, Koehler Maria, Powell Simon, Rosen Ezra, Galluzzi Lorenzo, Reis-Filho Jorge, Khan Atif, Riaz Nadeem

Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy.

基因型导向的 ATR 抑制与放射疗法的合成细胞毒性

Ng Victor, Sinha Sonali, Novaj Ardijana, Ma Jennifer, McDermott Niamh, Pei Xin, Longhini Ana Leda F, Grimsley Helen, Gardner Rui, Rosen Ezra, Powell Simon N, Pareja Fresia, Mandelker Diana, Khan Atif, Setton Jeremy, Roulston Anne, Morris Stephen, Koehler Maria, Lee Nancy, Reis-Filho Jorge, Riaz Nadeem

Author Correction: Improvement of Pharmacokinetic Profile of TRAIL via Trimer-Tag Enhances its Antitumor Activity in vivo

作者更正:通过三聚体标签改善TRAIL的药代动力学特征可增强其体内抗肿瘤活性

Liu, Haipeng; Su, Danmei; Zhang, Jinlong; Ge, Shuaishuai; Li, Youwei; Wang, Fei; Gravel, Michel; Roulston, Anne; Song, Qin; Xu, Wei; Liang, Joshua G; Shore, Gordon; Wang, Xiaodong; Liang, Peng

DZ-2384 has a superior preclinical profile to taxanes for the treatment of triple-negative breast cancer and is synergistic with anti-CTLA-4 immunotherapy

DZ-2384在治疗三阴性乳腺癌方面具有优于紫杉烷类药物的临床前特性,并且与抗CTLA-4免疫疗法具有协同作用。

Bernier, Cynthia; Soliman, Ahmed; Gravel, Michel; Dankner, Matthew; Savage, Paul; Petrecca, Kevin; Park, Morag; Siegel, Peter M; Shore, Gordon C; Roulston, Anne

The synthetic diazonamide DZ-2384 has distinct effects on microtubule curvature and dynamics without neurotoxicity

合成的重氮酰胺DZ-2384对微管曲率和动力学有显著影响,且无神经毒性。

Wieczorek, Michal; Tcherkezian, Joseph; Bernier, Cynthia; Prota, Andrea E; Chaaban, Sami; Rolland, Yannève; Godbout, Claude; Hancock, Mark A; Arezzo, Joseph C; Ocal, Ozhan; Rocha, Cecilia; Olieric, Natacha; Hall, Anita; Ding, Hui; Bramoullé, Alexandre; Annis, Matthew G; Zogopoulos, George; Harran, Patrick G; Wilkie, Thomas M; Brekken, Rolf A; Siegel, Peter M; Steinmetz, Michel O; Shore, Gordon C; Brouhard, Gary J; Roulston, Anne

New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology

肿瘤治疗中NAMPT抑制剂最大限度发挥治疗作用的新策略

Roulston, Anne; Shore, Gordon C

Programming cancer cells for high expression levels of Mcl1

对癌细胞进行编程,使其高表达Mcl1。

Ertel, Franziska; Nguyen, Mai; Roulston, Anne; Shore, Gordon C

The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors

小分子GMX1778是NAD+生物合成的强效抑制剂:增强烟酸磷酸核糖转移酶1缺陷型肿瘤治疗的策略

Watson, Mark; Roulston, Anne; Bélec, Laurent; Billot, Xavier; Marcellus, Richard; Bédard, Dominique; Bernier, Cynthia; Branchaud, Stéphane; Chan, Helen; Dairi, Kenza; Gilbert, Karine; Goulet, Daniel; Gratton, Michel-Olivier; Isakau, Henady; Jang, Anne; Khadir, Abdelkrim; Koch, Elizabeth; Lavoie, Manon; Lawless, Michael; Nguyen, Mai; Paquette, Denis; Turcotte, Emilie; Berger, Alvin; Mitchell, Matthew; Shore, Gordon C; Beauparlant, Pierre