日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular Modeling of ABHD5 Structure and Ligand Recognition

ABHD5结构及配体识别的分子建模

Shahoei, Rezvan; Pangeni, Susheel; Sanders, Matthew A; Zhang, Huamei; Mladenovic-Lucas, Ljiljana; Roush, William R; Halvorsen, Geoff; Kelly, Christopher V; Granneman, James G; Huang, Yu-Ming M

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.

通过对强效乙烯砜抑制剂的功能和结合模式分析,确定了血吸虫病组织蛋白酶 B1 靶点的可成药热点

Jílková Adéla, Rubešová Petra, Fanfrlík Jindřich, Fajtová Pavla, Řezáčová Pavlína, Brynda Jiří, Lepšík Martin, Mertlíková-Kaiserová Helena, Emal Cory D, Renslo Adam R, Roush William R, Horn Martin, Caffrey Conor R, Mareš Michael

An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation

一种具有异常pH敏感反应性的工程化精氨酸残基可促进位点选择性抗体偶联

Nilchan, Napon; Alburger, James M; Roush, William R; Rader, Christoph

Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study

基质金属蛋白酶-13抑制剂的开发——结构-活性/结构-性质关系研究

Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M; Smith, Lyndsay; Cameron, Michael D; Ruiz, Claudia; Fields, Gregg B; Roush, William R

Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri

鉴定半胱氨酸蛋白酶抑制剂作为对抗福氏耐格里阿米巴的新药先导化合物

Zyserman, Ingrid; Mondal, Deboprosad; Sarabia, Francisco; McKerrow, James H; Roush, William R; Debnath, Anjan

In Silico HTS and Structure Based Optimization of Indazole-Derived ULK1 Inhibitors

吲唑衍生的ULK1抑制剂的计算机高通量筛选和基于结构的优化

Wood, Spencer D; Grant, Wayne; Adrados, Isabel; Choi, Jun Yong; Alburger, James M; Duckett, Derek R; Roush, William R

Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes

新型药理学探针揭示ABHD5是白色和棕色脂肪细胞中脂肪分解控制的位点

Rondini, Elizabeth A; Mladenovic-Lucas, Ljiljana; Roush, William R; Halvorsen, Geoff T; Green, Alex E; Granneman, James G

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

靶向CYP51的4-氨基吡啶类先导化合物可预防慢性模型中的寄生虫自发复发,并改善克氏锥虫感染急性模型中的心脏病理。

Calvet, Claudia Magalhaes; Choi, Jun Yong; Thomas, Diane; Suzuki, Brian; Hirata, Ken; Lostracco-Johnson, Sharon; de Mesquita, Liliane Batista; Nogueira, Alanderson; Meuser-Batista, Marcelo; Silva, Tatiana Araujo; Siqueira-Neto, Jair Lage; Roush, William R; de Souza Pereira, Mirian Claudia; McKerrow, James H; Podust, Larissa M

Human Serum Albumin Domain I Fusion Protein for Antibody Conjugation

用于抗体偶联的人血清白蛋白结构域 I 融合蛋白

Patterson, James T; Wilson, Henry D; Asano, Shigehiro; Nilchan, Napon; Fuller, Roberta P; Roush, William R; Rader, Christoph; Barbas, Carlos F 3rd

CK1δ: an exploitable vulnerability in breast cancer

CK1δ:乳腺癌中一个可被利用的弱点

Rosenberg, Laura H; Cleveland, John L; Roush, William R; Duckett, Derek R