日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural Mechanism of an Efficacy Photoswitch Targeting the β(2)-adrenergic Receptor

靶向β(2)-肾上腺素能受体的高效光开关的结构机制

Stipp, Robin; Bertrand, Quentin; Trabuco, Matilde; Duran-Corbera, Anna; Ignazzitto, Maria Tindara; Glover, Hannah; Stierli, Fabienne; Catena, Juanlo; Carrillo, Melissa; Hartmann, Sina; Seidel, Hans-Peter; Mulder, Matthias; Mason, Thomas; Kondo, Yasushi; Wranik, Maximillian; Appleby, Martin; Sager, Christoph; Sierra, Raymond; Gate, Gregory; Schleissner, Pamela; Cheng, Xinxin; Weinert, Tobias; Cheng, Robert; Mous, Sandra; Beale, John H; Kepa, Michal; Llebaria, Amadeu; Hennig, Michael; Rovira, Xavier; Standfuss, Joerg

Light-Regulated Agonists Spatiotemporally Activating the Vitamin D Receptor Mitigate Psoriasis-like Inflammation in Mice without Inducing Hypercalcemia

光调控激动剂在时空上激活维生素D受体,可减轻小鼠银屑病样炎症,且不诱发高钙血症。

Rovira, Xavier; Espada, Alfonso; Serra, Carme; Catena, Juanlo; Lopez-Cano, Marc; Panarello, Silvia; Perez-Albaladejo, Elisabet; Broughton, Howard; Cano, Leticia; Ajieren, Hans; Khan, Sadid; Alvarez-Montoya, Paula; Muñoz, Lourdes; Font, Joan; Trapero, Ana; Rivero, Pablo; Li, Yanrong; Ma, Donghui; Yin, Xianglin; Ma, Yanfei L; Dodge, Jeffrey A; Dai, Mingji; Irazoqui, Pedro; Ciruela, Francisco; Krishnan, Venkatesh; Llebaria, Amadeu

Photoswitching endogenous glutamate receptors in neural ensembles and single synapses in vivo

在体内,通过光开关调控神经元群和单个突触中的内源性谷氨酸受体。

Garrido-Charles, Aida; Bosch, Miquel; Lee, Hyojung; Rovira, Xavier; Pittolo, Silvia; Llobet, Artur; Wong, Hovy Ho-Wai; Trapero, Ana; Matera, Carlo; Papotto, Claudio; Serra, Carme; Llebaria, Amadeu; Soriano, Eduardo; Sanchez-Vives, Maria V; Holt, Christine E; Gorostiza, Pau

Germline structural variant as the cause of Lynch Syndrome in a family from Ecuador

厄瓜多尔一个家族的林奇综合征是由种系结构变异引起的

Llargués-Sistac, Gemma; Bonjoch, Laia; Muñoz, Jenifer; Domínguez-Rovira, Xavier; Ocaña, Teresa; Alvarez-Mora, Maria Isabel; Badenas, Celia; Esteve-Codina, Anna; Reyes-Silva, Carlos; Jaramillo-Koupermann, Gabriela; Rodrigo, Maria Teresa; López-Prades, Sandra; Cuatrecasas, Miriam; Castells, Antoni; Balaguer, Francesc; Moreira, Leticia; Fernandez, Guerau; Castellví-Bel, Sergi

Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndrome.

HIC1 DNA 结合域的种系致病变异与家族性锯齿状息肉综合征有关

Domínguez-Rovira Xavier, Arnau-Collell Coral, Gonfaus-Ortiz Gemma, Llargués-Sistac Gemma, Muñoz Jenifer, Llopis Ainara, Soares de Lima Yasmin, Herrera-Pariente Cristina, Moreira Leticia, Ocaña Teresa, Díaz-Gay Marcos, Cuatrecasas Miriam, Carballal Sabela, López-Novo Anael, Fernàndez Guerau, Castells Antoni, Bujanda Luis, Capellà Gabriel, Cubiella Joaquín, Rodríguez-Alcalde Daniel, Valle Laura, Balaguer Francesc, Ruiz-Ponte Clara, Bonjoch Laia, Castellví-Bel Sergi

A Photoswitchable Ligand Targeting the β(1) -Adrenoceptor Enables Light-Control of the Cardiac Rhythm

一种靶向β(1)-肾上腺素受体的光开关配体可实现对心脏节律的光控

Duran-Corbera, Anna; Faria, Melissa; Ma, Yuanyuan; Prats, Eva; Dias, André; Catena, Juanlo; Martinez, Karen L; Raldua, Demetrio; Llebaria, Amadeu; Rovira, Xavier

Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface.

变构配体通过作用于跨膜界面来控制 C 类 GPCR 异二聚体的激活

Liu Lei, Fan Zhiran, Rovira Xavier, Xue Li, Roux Salomé, Brabet Isabelle, Xin Mingxia, Pin Jean-Philippe, Rondard Philippe, Liu Jianfeng

Mechanistic Insights into Light-Driven Allosteric Control of GPCR Biological Activity

光驱动变构调控GPCR生物活性的机制研究

Ricart-Ortega, Maria; Berizzi, Alice E; Pereira, Vanessa; Malhaire, Fanny; Catena, Juanlo; Font, Joan; Gómez-Santacana, Xavier; Muñoz, Lourdes; Zussy, Charleine; Serra, Carmen; Rovira, Xavier; Goudet, Cyril; Llebaria, Amadeu

Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

与GPCR异源寡聚体激活相关的跨膜结构域界面重排

Xue, Li; Sun, Qian; Zhao, Han; Rovira, Xavier; Gai, Siyu; He, Qianwen; Pin, Jean-Philippe; Liu, Jianfeng; Rondard, Philippe

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

更正:利用光敏mGlu5受体负变构调节剂对体内疼痛进行光学控制

Font, Joan; López-Cano, Marc; Notartomaso, Serena; Scarselli, Pamela; Di Prieto, Paola; Bresolí-Obach, Roger; Battaglia, Giuseppe; Malhaire, Fanny; Rovira, Xavier; Catena, Juanlo; Giraldo, Jesús; Pin, Jean-Philippe; Fernández-Dueñas, Víctor; Goudet, Cyril; Nonell, Santi; Nicoletti, Ferdinando; Llebaria, Amadeu; Ciruela, Francisco