日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds

基于模型识别 TNFα 诱导的 IKKβ 介导和 IκBα 介导的 NFκB 信号转导调控,作为量化药物性肝损伤化合物影响的工具

Angela Oppelt #, Daniel Kaschek #, Suzanna Huppelschoten, Rowena Sison-Young, Fang Zhang, Marie Buck-Wiese, Franziska Herrmann, Sebastian Malkusch, Carmen L Krüger, Mara Meub, Benjamin Merkt, Lea Zimmermann, Amy Schofield, Robert P Jones, Hassan Malik, Marcel Schilling, Mike Heilemann, Bob van de Wa

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

利用干细胞衍生模型提高对人类药物性肝损伤机制的理解和预测能力

Goldring, Christopher; Antoine, Daniel J; Bonner, Frank; Crozier, Jonathan; Denning, Chris; Fontana, Robert J; Hanley, Neil A; Hay, David C; Ingelman-Sundberg, Magnus; Juhila, Satu; Kitteringham, Neil; Silva-Lima, Beatriz; Norris, Alan; Pridgeon, Chris; Ross, James A; Young, Rowena Sison; Tagle, Danilo; Tornesi, Belen; van de Water, Bob; Weaver, Richard J; Zhang, Fang; Park, B Kevin

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

使用整体蛋白质组学分析对原代人肝细胞培养进行机制评估,揭示了选择性去分化特征

James A Heslop, Cliff Rowe, Joanne Walsh, Rowena Sison-Young, Roz Jenkins, Laleh Kamalian, Richard Kia, David Hay, Robert P Jones, Hassan Z Malik, Stephen Fenwick, Amy E Chadwick, John Mills, Neil R Kitteringham, Chris E P Goldring, B Kevin Park

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

表型和功能分析表明,干细胞衍生的肝细胞样细胞比成人肝细胞更好地模拟胎儿肝细胞

Melissa Baxter, Sarah Withey, Sean Harrison, Charis-Patricia Segeritz, Fang Zhang, Rebecca Atkinson-Dell, Cliff Rowe, Dave T Gerrard, Rowena Sison-Young, Roz Jenkins, Joanne Henry, Andrew A Berry, Lisa Mohamet, Marie Best, Stephen W Fenwick, Hassan Malik, Neil R Kitteringham, Chris E Goldring, Karen

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

Nrf2 缺陷转基因小鼠的蛋白质组学分析表明,细胞防御和脂质代谢是肝脏中主要的 Nrf2 依赖性途径

Neil R Kitteringham, Azman Abdullah, Joanne Walsh, Laura Randle, Rosalind E Jenkins, Rowena Sison, Christopher E P Goldring, Helen Powell, Christopher Sanderson, Samantha Williams, Larry Higgins, Masayuki Yamamoto, John Hayes, B Kevin Park