日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice

免疫抑制可以克服胰岛素和载体特异性免疫反应,从而降低AAV2/8介导的胰岛素基因疗法在NOD小鼠中的疗效。

Asha Recino ,Shu Uin Gan ,Kian Chuan Sia ,Yvonne Sawyer ,Jenny Trendell ,Richard Kay ,Fiona M Gribble ,Frank Reimann ,Rob Foale ,Maria Notaridou ,Nick Holmes ,Andrew Lever ,Kok Onn Lee ,Amit Nathwani ,Anne Cooke ,Roy Calne ,Maja Wallberg

Development of a liver-specific Tet-off AAV8 vector for improved safety of insulin gene therapy for diabetes

开发肝脏特异性Tet-off AAV8载体以提高糖尿病胰岛素基因治疗的安全性

Shu Uin Gan, Zhenying Fu, Kian Chuan Sia, Oi Lian Kon, Roy Calne, Kok Onn Lee