日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia

Pinometostat (EPZ-5676) 治疗导致 MLL 重排白血病出现耐药性的机制

Carly T Campbell, Jessica N Haladyna, David A Drubin, Ty M Thomson, Michael J Maria, Taylor Yamauchi, Nigel J Waters, Edward J Olhava, Roy M Pollock, Jesse J Smith, Robert A Copeland, Stephen J Blakemore, Kathrin M Bernt, Scott R Daigle

MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia

MLL1 和 DOT1L 与脑膜瘤-1 协同诱发急性髓系白血病

Simone S Riedel, Jessica N Haladyna, Matthew Bezzant, Brett Stevens, Daniel A Pollyea, Amit U Sinha, Scott A Armstrong, Qi Wei, Roy M Pollock, Scott R Daigle, Craig T Jordan, Patricia Ernst, Tobias Neff, Kathrin M Bernt

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

EZH2 抑制在人类滑膜肉瘤模型中诱导抗肿瘤活性的临床前证据

Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Galina Kuznetsov, Shanqin Xu, Yonghong Xiao, Roy M Pollock, Jesse S Smith, Kevin K Kuntz, Scott Ribich, Yukinori Minoshima, Junji Matsui, Robert A Copeland, Shinya Tanaka, Heike Keilhack

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

结构和性能引导设计在 PRMT5 工具化合物 EPZ015666 识别中的应用

Kenneth W Duncan, Nathalie Rioux, P Ann Boriack-Sjodin, Michael J Munchhof, Lawrence A Reiter, Christina R Majer, Lei Jin, L Danielle Johnston, Elayne Chan-Penebre, Kristy G Kuplast, Margaret Porter Scott, Roy M Pollock, Nigel J Waters, Jesse J Smith, Mikel P Moyer, Robert A Copeland, Richard Cheswo

Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

EZH2 抑制剂和糖皮质激素受体激动剂在生发中心非霍奇金淋巴瘤模型中的协同抗肿瘤活性

Sarah K Knutson, Natalie M Warholic, L Danielle Johnston, Christine R Klaus, Tim J Wigle, Dorothy Iwanowicz, Bruce A Littlefield, Margaret Porter-Scott, Jesse J Smith, Mikel P Moyer, Robert A Copeland, Roy M Pollock, Kevin W Kuntz, Alejandra Raimondi, Heike Keilhack

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

通过抑制甲基转移酶 EZH2 实现基因改变的恶性横纹肌样瘤的持久肿瘤消退

Sarah K Knutson, Natalie M Warholic, Tim J Wigle, Christine R Klaus, Christina J Allain, Alejandra Raimondi, Margaret Porter Scott, Richard Chesworth, Mikel P Moyer, Robert A Copeland, Victoria M Richon, Roy M Pollock, Kevin W Kuntz, Heike Keilhack

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

野生型和突变型 EZH2 的协同作用导致人类 B 细胞淋巴瘤中组蛋白 H3 上赖氨酸 27 (H3K27) 发生肿瘤相关的高三甲基化

Christopher J Sneeringer, Margaret Porter Scott, Kevin W Kuntz, Sarah K Knutson, Roy M Pollock, Victoria M Richon, Robert A Copeland