日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy

微调 BACH2 剂量可平衡干细胞特性和效应功能,从而增强抗肿瘤 T 细胞疗法。

Conti, Alberto G; Evans, Alexander C; von Linde, Teresa; Deguit, Christian Deo T; Whiteside, Sarah K; Wesolowski, Alexander J; Imianowski, Charlotte J; Yamashita-Kanemaru, Yumi; Dahmani, Layla; Chapman, Jack; Pillay, Ardon M; Al-Deka, Aws; Greaves, Randy; Burton, Oliver; Vardaka, Panagiota; Sampurno, Shienny; Pérez-Núñez, Iván; Saw, Nicole Y L; Yang, Jie; Howden, Andrew J M; Okkenhaug, Klaus; Mitra, Suman; Swiatczak, Bartlomiej; Parish, Ian A; Roychoudhuri, Rahul

Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer

皮质醇耐受性CAR-NK细胞可克服肺癌中类固醇诱导的免疫抑制

Chakraborty, Soura; Pramanik, Jhuma; Alviter-Raymundo, Gustavo; Ward, Christopher J; Shaji, Sanu K; Yamashita-Kanemaru, Yumi; Ali, Fatma Abo Zakaib; Banik, Debasis; Zhang, Ziwei; Veiga-Villauriz, Clara; Homer, Natalie Z M; Simpson, Joanna; Laforest, Sofia; Tong, Shanlin; Zhao, Qiuchen; Roy, James; Iqbal, Muhammad; Morris, Andrew Conway; Chapman, Michael A; Roychoudhuri, Rahul; Hussein, Hosni; Klenerman, David; Saeb-Parsy, Kourosh; Mahata, Bidesh

Perturbing local steroidogenesis to improve breast cancer immunity.

干扰局部类固醇生成以提高乳腺癌免疫力

Zhao Qiuchen, Pramanik Jhuma, Lu Yongjin, Homer Natalie Z M, Imianowski Charlotte J, Zhang Baojie, Iqbal Muhammad, Shaji Sanu Korumadathil, Morris Andrew Conway, Roychoudhuri Rahul, Okkenhaug Klaus, Qiu Pengfei, Mahata Bidesh

Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site

肿瘤内抗原信号传导会捕获 CD8(+) T 细胞,从而将 T 细胞耗竭限制在肿瘤部位。

Takahashi, Munetomo; So, Tsz Y; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y F; Lyons, Paul A; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J; Smith, Ken G C; Jodrell, Duncan I; Chapman, Michael A; Thaventhiran, James E D

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.

调节性 T 细胞中缺乏磷脂酰肌醇 3-激酶 VPS34 会导致致命的淋巴增生性疾病,但并不影响其发育

Courreges Christina J F, Davenport Elizabeth C M, Bilanges Benoit, Rebollo-Gomez Elena, Hukelmann Jens, Schoenfelder Priya, Edgar James R, Sansom David, Scudamore Cheryl L, Roychoudhuri Rahul, Garden Oliver A, Vanhaesebroeck Bart, Okkenhaug Klaus

Acquisition of suppressive function by conventional T cells limits antitumor immunity upon T(reg) depletion

传统T细胞获得抑制功能后,T(reg)细胞耗竭会限制抗肿瘤免疫力。

Whiteside, Sarah K; Grant, Francis M; Alvisi, Giorgia; Clarke, James; Tang, Leqi; Imianowski, Charlotte J; Zhang, Baojie; Evans, Alexander C; Wesolowski, Alexander J; Conti, Alberto G; Yang, Jie; Lauder, Sarah N; Clement, Mathew; Humphreys, Ian R; Dooley, James; Burton, Oliver; Liston, Adrian; Alloisio, Marco; Voulaz, Emanuele; Langhorne, Jean; Okkenhaug, Klaus; Lugli, Enrico; Roychoudhuri, Rahul

DIPG-53. LSD1 DEGRADATION SYNERGIZES WITH HDAC INHIBITION IN PEDIATRIC H3K27M DIFFUSE MIDLINE GLIOMA

DIPG-53。LSD1降解与HDAC抑制在儿童H3K27M弥漫性中线胶质瘤中具有协同作用

Collier, Camille; Wucherer, Kelly; McWhorter, Matthew; Jenkins, Chelsea; Bartlett, Alexandra; Roychoudhuri, Rahul; Eil, Robert; Haase, Rebecca; Groves, Andrew; Mire, Hafsa; Qi, Jun; Filbin, Mariella

BACH2 restricts NK cell maturation and function, limiting immunity to cancer metastasis

BACH2限制NK细胞的成熟和功能,从而限制机体对癌症转移的免疫力。

Imianowski, Charlotte J; Whiteside, Sarah K; Lozano, Teresa; Evans, Alexander C; Benson, Jayme D; Courreges, Christina J F; Sadiyah, Firas; Lau, Colleen M; Zandhuis, Nordin D; Grant, Francis M; Schuijs, Martijn J; Vardaka, Panagiota; Kuo, Paula; Soilleux, Elizabeth J; Yang, Jie; Sun, Joseph C; Kurosaki, Tomohiro; Okkenhaug, Klaus; Halim, Timotheus Y F; Roychoudhuri, Rahul

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

CCR8 标记肿瘤内具有高度抑制性的 Treg 细胞,但对于这些细胞的积累和抑制功能并非必需。

Whiteside, Sarah K; Grant, Francis M; Gyori, David S; Conti, Alberto G; Imianowski, Charlotte J; Kuo, Paula; Nasrallah, Rabab; Sadiyah, Firas; Lira, Sergio A; Tacke, Frank; Eil, Robert L; Burton, Oliver T; Dooley, James; Liston, Adrian; Okkenhaug, Klaus; Yang, Jie; Roychoudhuri, Rahul

A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE

炎症性肠病患者结肠来源肠类器官中A202内质网应激通路失调驱动树突状细胞成熟,导致促炎表型

Ji, Yun; Wrzesinski, Claudia; Yu, Zhiya; Hu, Jinhui; Gautam, Sanjivan; Hawk, Nga V; Telford, William G; Palmer, Douglas C; Franco, Zulmarie; Sukumar, Madhusudhanan; Roychoudhuri, Rahul; Clever, David; Klebanoff, Christopher A; Surh, Charles D; Waldmann, Thomas A; Restifo, Nicholas P; Gattinoni, Luca; Rees, W D; Stahl, M; Jacobson, K; Bressler, B; Sly, L M; Vallance, B; Steiner, T