Rozen Rima相关文献与解析，生知库 | 链接生命科学的每一步

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant

磷脂酰胆碱和甜菜碱补充剂对MTHFD1 R653Q变异小鼠模型胚胎发育的对比效应

期刊:Journal of Nutrition

影响因子:3.8

doi:10.1016/j.tjnut.2025.07.013

Christensen, Karen E; Faquette, Marie-Lou; Gebert, Aaron T; Keser, Vafa; Bottiglieri, Teodoro; Rozen, Rima

Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr(677C>T) Mouse Model with Hepatic Steatosis.

在患有肝脂肪变性的 Mthfr(677C>T) 小鼠模型中补充叶酸和甲基四氢叶酸

期刊:Nutrients

影响因子:5

doi:10.3390/nu17010082

Christensen Karen E, Faquette Marie-Lou, Leclerc Daniel, Keser Vafa, Luan Yan, Bennett-Firmin Jeanna L, Malysheva Olga V, Reagan Alaina M, Howell Gareth R, Caudill Marie A, Bottiglieri Teodoro, Rozen Rima

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation

5,10-亚甲基四氢叶酸还原酶677C>T变异小鼠模型中精子DNA甲基化缺陷及其通过中等剂量叶酸补充的纠正

期刊:Molecular Human Reproduction

影响因子:

doi:10.1093/molehr/gaae008

Martínez Duncker Rebolledo, Edgar; Chan, Donovan; Christensen, Karen E; Reagan, Alaina M; Howell, Gareth R; Rozen, Rima; Trasler, Jacquetta

Shifting landscapes of human MTHFR missense-variant effects

人类MTHFR错义变异效应的格局正在发生变化

期刊:American Journal of Human Genetics

影响因子:8.1

doi:10.1016/j.ajhg.2021.05.009

Weile, Jochen; Kishore, Nishka; Sun, Song; Maaieh, Ranim; Verby, Marta; Li, Roujia; Fotiadou, Iosifina; Kitaygorodsky, Julia; Wu, Yingzhou; Holenstein, Alexander; Bürer, Céline; Blomgren, Linnea; Yang, Shan; Nussbaum, Robert; Rozen, Rima; Watkins, David; Gebbia, Marinella; Kozich, Viktor; Garton, Michael; Froese, D Sean; Roth, Frederick P

发表日期：2021

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Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

孕鼠补充适量叶酸会导致子代行为改变，并伴有性别特异性的甲基代谢变化。

期刊:Nutrients

影响因子:5

doi:10.3390/nu12061716

Cosín-Tomás, Marta; Luan, Yan; Leclerc, Daniel; Malysheva, Olga V; Lauzon, Nidia; Bahous, Renata H; Christensen, Karen E; Caudill, Marie A; Rozen, Rima

代谢

发表日期：2020

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High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

妊娠小鼠摄入高叶酸会导致假性MTHFR缺乏症和甲基代谢紊乱，进而导致胚胎生长迟缓和子代短期记忆障碍。

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddx004

Bahous, Renata H; Jadavji, Nafisa M; Deng, Liyuan; Cosín-Tomás, Marta; Lu, Jessica; Malysheva, Olga; Leung, Kit-Yi; Ho, Ming-Kai; Pallàs, Mercè; Kaliman, Perla; Greene, Nicholas D E; Bedell, Barry J; Caudill, Marie A; Rozen, Rima

代谢

发表日期：2017

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Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice

Mthfr 作为 Crb1(rd8/rd8) 小鼠视网膜表型的修饰因子

期刊:Experimental Eye Research

影响因子:2.7

doi:10.1016/j.exer.2015.11.013

Markand, Shanu; Saul, Alan; Tawfik, Amany; Cui, Xuezhi; Rozen, Rima; Smith, Sylvia B

发表日期：2016

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Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

突变型卷尾（Grhl3）胚胎中叶酸缺乏引起的神经管缺陷与叶酸一碳代谢的改变有关，但不太可能是由甲基化减少所致。

期刊:

影响因子:

doi:10.1002/bdra.20690

De Castro, Sandra C P; Leung, Kit-Yi; Savery, Dawn; Burren, Katie; Rozen, Rima; Copp, Andrew J; Greene, Nicholas D E

Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption

叶酸载体80A→G多态性降低、血浆叶酸水平与胎盘早剥风险

期刊:Human Genetics

影响因子:3.6

doi:10.1007/s00439-008-0531-7

Ananth, Cande V; Peltier, Morgan R; Moore, Dirk F; Kinzler, Wendy L; Leclerc, Daniel; Rozen, Rima R

发表日期：2008

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Low Dietary Folate Increases Developmental Delays in the Litters of Mthfr(677TT) Mice.

低膳食叶酸会增加 Mthfr(677TT) 小鼠幼崽的发育迟缓

Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant

磷脂酰胆碱和甜菜碱补充剂对MTHFD1 R653Q变异小鼠模型胚胎发育的对比效应

Folic Acid and Methyltetrahydrofolate Supplementation in the Mthfr(677C>T) Mouse Model with Hepatic Steatosis.

在患有肝脂肪变性的 Mthfr(677C>T) 小鼠模型中补充叶酸和甲基四氢叶酸

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation

5,10-亚甲基四氢叶酸还原酶677C>T变异小鼠模型中精子DNA甲基化缺陷及其通过中等剂量叶酸补充的纠正

Shifting landscapes of human MTHFR missense-variant effects

人类MTHFR错义变异效应的格局正在发生变化

Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism

孕鼠补充适量叶酸会导致子代行为改变，并伴有性别特异性的甲基代谢变化。

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

妊娠小鼠摄入高叶酸会导致假性MTHFR缺乏症和甲基代谢紊乱，进而导致胚胎生长迟缓和子代短期记忆障碍。

Mthfr as a modifier of the retinal phenotype of Crb1(rd8/rd8) mice

Mthfr 作为 Crb1(rd8/rd8) 小鼠视网膜表型的修饰因子

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

突变型卷尾（Grhl3）胚胎中叶酸缺乏引起的神经管缺陷与叶酸一碳代谢的改变有关，但不太可能是由甲基化减少所致。

Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption

叶酸载体80A→G多态性降低、血浆叶酸水平与胎盘早剥风险