Rozengurt相关文献与解析，生知库 | 链接生命科学的每一步

Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells

Piezo1通道的激活可刺激人主动脉内皮细胞中的蛋白激酶D和细胞迁移。

期刊:American Journal of Physiology-Cell Physiology

影响因子:4.7

doi:10.1152/ajpcell.00457.2025

Lone, Moien; Singh, Parvind; Sinnett-Smith, James; Jin, Yi-Ping; Reed, Elaine F; Rozengurt, Enrique

Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer.

压力和肥胖信号通过 CREB 磷酸化促进胰腺癌的发生

期刊:Molecular Cancer Research

影响因子:4.7

doi:10.1158/1541-7786.MCR-24-0785

Sun Xiaoying, Teper Yaroslav, Sinnett-Smith James, Markarian Mineh, Hines O Joe, Li Gang, Eibl Guido, Rozengurt Enrique

Antibody ligation of HLA class II induces YAP nuclear localization and formation of cytoplasmic YAP condensates in human endothelial cells

抗体与HLA II类分子结合可诱导人内皮细胞中YAP的核定位和胞质YAP凝聚体的形成。

期刊:Immunohorizons

影响因子:

doi:10.1093/immhor/vlae008

Lone, Moien; Anwar, Tarique; Sinnett-Smith, James; Jin, Yi-Ping; Reed, Elaine F; Rozengurt, Enrique

Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy

在抗体介导的排斥和同种异体移植血管病模型中，人类白细胞抗原 I 类抗体激活的内皮细胞通过 TLR4 信号和 P 选择素促进 CD206+ M2 巨噬细胞极化和 MMP9 分泌

期刊:American Journal of Transplantation

影响因子:8.9

doi:10.1016/j.ajt.2023.10.020

Jessica Nevarez-Mejia, Yi-Ping Jin, Harry Pickering, Rajesh Parmar, Nicole M Valenzuela, Rebecca A Sosa, Sebastiaan Heidt, Gregory A Fishbein, Enrique Rozengurt, William M Baldwin 3rd, Robert L Fairchild, Elaine F Reed

Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma

上调的基质蛋白和细胞外基质机械信号是肥胖相关胰腺导管腺癌发生的基础

期刊:Cancers

影响因子:

doi:10.3390/cancers16081593

Richard T Waldron, Aurelia Lugea, Hui-Hua Chang, Hsin-Yuan Su, Crystal Quiros, Michael S Lewis, Mingtian Che, V Krishnan Ramanujan, Enrique Rozengurt, Guido Eibl, Stephen J Pandol

Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids

他汀类药物抑制肠道细胞中的蛋白激酶 D (PKD) 活化并阻止 PKD1 诱导的小鼠肠道类固醇生长

期刊:American Journal of Physiology-Cell Physiology

影响因子:5

doi:10.1152/ajpcell.00286.2022

James Sinnett-Smith, M Eugenia Torres-Marquez, Jen-Kuan Chang, Yuki Shimizu, Fang Hao, Martin G Martin, Enrique Rozengurt

Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton

亲脂性他汀类药物通过 Rho 介导的肌动蛋白细胞骨架调节来抑制肝癌细胞中的 YAP 辅激活因子转录活性

期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology

影响因子:3.9

doi:10.1152/ajpgi.00089.2023

Jihane N Benhammou, Bo Qiao, Arthur Ko, James Sinnett-Smith, Joseph R Pisegna, Enrique Rozengurt

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

低剂量二甲双胍和辛伐他汀联合治疗可抑制雄性 KrasG12D 小鼠肥胖促进的胰腺癌发展

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-023-43498-9

Yaroslav Teper #, Linda Ye #, Richard T Waldron, Aurelia Lugea, Xiaoying Sun, James Sinnett-Smith, Oscar J Hines, Stephen J Pandol, Enrique Rozengurt, Guido Eibl

Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation

亲脂性他汀类药物抑制内皮细胞中 HLA I 类分子连接引起的 YAP 核定位、辅激活因子活性和迁移：YAP 多位点磷酸化的作用

期刊:Journal of Immunology

影响因子:3.6

doi:10.4049/jimmunol.2200568

Tarique Anwar, James Sinnett-Smith, Yi-Ping Jin, Elaine F Reed, Enrique Rozengurt

Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies

胰腺癌：分子发病机制和新兴治疗策略

Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells

Piezo1通道的激活可刺激人主动脉内皮细胞中的蛋白激酶D和细胞迁移。

Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer.

压力和肥胖信号通过 CREB 磷酸化促进胰腺癌的发生

Antibody ligation of HLA class II induces YAP nuclear localization and formation of cytoplasmic YAP condensates in human endothelial cells

抗体与HLA II类分子结合可诱导人内皮细胞中YAP的核定位和胞质YAP凝聚体的形成。

Human leukocyte antigen class I antibody-activated endothelium promotes CD206+ M2 macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy

在抗体介导的排斥和同种异体移植血管病模型中，人类白细胞抗原 I 类抗体激活的内皮细胞通过 TLR4 信号和 P 选择素促进 CD206+ M2 巨噬细胞极化和 MMP9 分泌

Upregulated Matrisomal Proteins and Extracellular Matrix Mechanosignaling Underlie Obesity-Associated Promotion of Pancreatic Ductal Adenocarcinoma

上调的基质蛋白和细胞外基质机械信号是肥胖相关胰腺导管腺癌发生的基础

Statins inhibit protein kinase D (PKD) activation in intestinal cells and prevent PKD1-induced growth of murine enteroids

他汀类药物抑制肠道细胞中的蛋白激酶 D (PKD) 活化并阻止 PKD1 诱导的小鼠肠道类固醇生长

Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton

亲脂性他汀类药物通过 Rho 介导的肌动蛋白细胞骨架调节来抑制肝癌细胞中的 YAP 辅激活因子转录活性

Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice

低剂量二甲双胍和辛伐他汀联合治疗可抑制雄性 KrasG12D 小鼠肥胖促进的胰腺癌发展

Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation

亲脂性他汀类药物抑制内皮细胞中 HLA I 类分子连接引起的 YAP 核定位、辅激活因子活性和迁移：YAP 多位点磷酸化的作用