日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target

NADase CD38 是痛风炎症的中心调节剂,也是新的可用药治疗靶点

Paulo Gil Alabarse, Patricia Oliveira, Huaping Qin, Tiffany Yan, Marie Migaud, Robert Terkeltaub, Ru Liu-Bryan

Protocol for preparing monosodium urate crystals for in vitro and in vivo studies in mouse and human cells

用于小鼠和人细胞体外和体内研究的单钠尿酸盐晶体制备方案

Mohnish Alishala ,Ru Liu-Bryan ,Isidoro Cobo

Monosodium urate crystals regulate a unique JNK-dependent macrophage metabolic and inflammatory response

单钠尿酸盐晶体调节独特的 JNK 依赖性巨噬细胞代谢和炎症反应

Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K Glass, Monica Guma

A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response

对果蝇嘌呤代谢物的 GWAS 关联分析识别出人类 FAM214 同源物 medusa,它以保守的方式通过调节嘌呤代谢和炎症反应来增强高尿酸血症引起的病理

Tyler A U Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N Beck, Sven Lang, Kelly Jin, Christopher S Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B Brem, Robert Terkeltaub, Pankaj Kapahi4

Cartilage-targeting ultrasmall lipid-polymer hybrid nanoparticles for the prevention of cartilage degradation

针对软骨的超小脂质聚合物混合纳米粒子可用于预防软骨退化

Xiangzhao Ai, Yaou Duan, Qiangzhe Zhang, Derrick Sun, Ronnie H Fang, Ru Liu-Bryan, Weiwei Gao, Liangfang Zhang

Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production

胆碱的吸收和代谢调节巨噬细胞 IL-1β 和 IL-18 的产生

Elsa Sanchez-Lopez, Zhenyu Zhong, Alexandra Stubelius, Shannon R Sweeney, Laela M Booshehri, Laura Antonucci, Ru Liu-Bryan, Alessia Lodi, Robert Terkeltaub, Juan Carlos Lacal, Anne N Murphy, Hal M Hoffman, Stefano Tiziani, Monica Guma, Michael Karin

A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia

血管平滑肌细胞 X-box 结合蛋白 1 和转谷氨酰胺酶 2 调节回路限制内膜增生

Ramon L Serrano, Weifang Yu, Robert M Graham, Ru Liu- Bryan, Robert Terkeltaub

Impaired Proteasomal Function in Human Osteoarthritic Chondrocytes Can Contribute to Decreased Levels of SOX9 and Aggrecan

人类骨关节炎软骨细胞中蛋白酶体功能受损可导致 SOX9 和 Aggrecan 水平降低

Ramon L Serrano, Liang-Yu Chen, Martin K Lotz, Ru Liu-Bryan, Robert Terkeltaub

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

芳卤芬酸通过激活 AMP 活化蛋白激酶 (AMPK) 信号抑制尿酸钠晶体诱发的炎症反应

Charles McWherter, Yun-Jung Choi, Ramon L Serrano, Sushil K Mahata, Robert Terkeltaub, Ru Liu-Bryan

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α

骨关节炎软骨细胞中的线粒体生物合成受损,但可通过过氧化物酶体增殖激活受体γ辅激活因子1α逆转

Yun Wang, Xianling Zhao, Martin Lotz, Robert Terkeltaub, Ru Liu-Bryan