A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response
对果蝇嘌呤代谢物的 GWAS 关联分析识别出人类 FAM214 同源物 medusa,它以保守的方式通过调节嘌呤代谢和炎症反应来增强高尿酸血症引起的病理
期刊:Geroscience
影响因子:5.3
doi:10.1007/s11357-022-00557-9
Tyler A U Hilsabeck, Ru Liu-Bryan, Tracy Guo, Kenneth A Wilson, Neelanjan Bose, Daniel Raftery, Jennifer N Beck, Sven Lang, Kelly Jin, Christopher S Nelson, Tal Oron, Marshall Stoller, Daniel Promislow, Rachel B Brem, Robert Terkeltaub, Pankaj Kapahi4