Administration of a CXC Chemokine Receptor 2 (CXCR2) Antagonist, SCH527123, Together with Oseltamivir Suppresses NETosis and Protects Mice from Lethal Influenza and Piglets from Swine-Influenza Infection
CXC趋化因子受体2 (CXCR2) 拮抗剂SCH527123与奥司他韦联合使用可抑制中性粒细胞胞外陷阱形成 (NETosis),并保护小鼠免受致命性流感病毒感染,以及保护仔猪免受猪流感病毒感染。
期刊:American Journal of Pathology
影响因子:3.6
doi:10.1016/j.ajpath.2020.12.013
Ashar, Harshini K; Pulavendran, Sivasami; Rudd, Jennifer M; Maram, Prasanthi; Achanta, Mallika; Chow, Vincent T K; Malayer, Jerry R; Snider, Timothy A; Teluguakula, Narasaraju
CR2
NETosis
中性粒细胞
炎症/感染
信号转导
流感
粒细胞
微生物学
CXCR2
细胞生物学
免疫/内分泌