日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases

鉴定能够阻断K-Ras及其他Ras超家族小GTP酶成员GTP结合口袋的小分子抑制剂

Carta, Luca; Hutcheson, Rebecca; Bigarella, Carolina L; Zhang, Sufang; Davis, Simon A; Rudolph, Michael J; Reynolds, Charles H; Quick, Matthias; Williams, Theresa M; Schmertzler, Michael; Hadari, Yaron R

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge

一种Fc沉默的OspA单克隆抗体可被动保护小鼠免受蜱虫和皮内伯氏疏螺旋体感染。

Palmer, Daniel; Shemshadian, Atieh; Berman, Katherine; Nobles, Ariana; Willsey, Graham G; Piazza, Carol Lyn; Freeman-Gallant, Grace; Rudolph, Michael J; Bourgeois, Jeff; Hu, Linden; Vance, David J; Mantis, Nicholas J

Donor strand complementation and calcium ion coordination drive the chaperone-free polymerization of archaeal cannulae

供体链互补和钙离子配位驱动古细菌插管的无分子伴侣聚合

Sleutel, Mike; Sonani, Ravi R; Miller, Jessalyn G; Wang, Fengbin; Gonzalez Socorro, Andres; Chen, Yang; Martin, Reece; Demeler, Borries; Rudolph, Michael J; Alva, Vikram; Remaut, Han; Egelman, Edward H; Conticello, Vincent P

Binding of small molecules at the P-stalk site of ricin A subunit trigger conformational changes that extend into the active site.

小分子与蓖麻毒素 A 亚基 P 茎位点的结合会引发构象变化,进而延伸至活性位点

McLaughlin John E, Rudolph Michael J, Dutta Arkajyoti, Li Xiao-Ping, Tsymbal Anastasiia M, Chen Yang, Bhattacharya Shibani, Algava Benjamin, Goger Michael, Roberge Jacques Y, Tumer Nilgun E

A type-specific B-cell epitope at the apex of outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

莱姆病螺旋体伯氏疏螺旋体(Borreliella burgdorferi)外表面蛋白C(OspC)顶端的一种类型特异性B细胞表位

Vance, David J; Freeman-Gallant, Grace; McCarthy, Kathleen; Piazza, Carol Lyn; Chen, Yang; Vorauer, Clint; Muriuki, Beatrice; Rudolph, Michael J; Cavacini, Lisa; Guttman, Miklos; Mantis, Nicholas J

Fragment Screening to Identify Inhibitors Targeting Ribosome Binding of Shiga Toxin 2

利用片段筛选鉴定靶向志贺毒素2核糖体结合的抑制剂

Rudolph, Michael J; Tsymbal, Anastasiia M; Dutta, Arkajyoti; Davis, Simon A; Algava, Benjamin; Roberge, Jacques Y; Tumer, Nilgun E; Li, Xiao-Ping

Single-domain antibodies reveal unique borrelicidal epitopes on the Lyme disease vaccine antigen, outer surface protein A (OspA)

单域抗体揭示了莱姆病疫苗抗原——外表面蛋白A(OspA)上独特的杀灭伯氏疏螺旋体表位

Vance, David J; Basir, Saiful; Piazza, Carol Lyn; Willsey, Graham G; Haque, H M Emranul; Tremblay, Jacque M; Rudolph, Michael J; Muriuki, Beatrice; Cavacini, Lisa; Weis, David D; Shoemaker, Charles B; Mantis, Nicholas J

(1)H, (13)C, and (15)N backbone and methyl group resonance assignments of ricin toxin A subunit

蓖麻毒素A亚基的(1)H、(13)C和(15)N骨架和甲基共振归属

Bhattacharya, Shibani; Dahmane, Tassadite; Goger, Michael J; Rudolph, Michael J; Tumer, Nilgun E

Donor Strand Complementation and Calcium Ion Coordination Drive the Chaperone-free Polymerization of Archaeal Cannulae

供体链互补和钙离子配位驱动古细菌插管的无分子伴侣聚合

Sleutel, Mike; Sonani, Ravi R; Miller, Jessalyn G; Wang, Fengbin; Socorro, Andres Gonzalez; Chen, Yang; Martin, Reece; Demeler, Borries; Rudolph, Michael J; Alva, Vikram; Remaut, Han; Egelman, Edward H; Conticello, Vincent P

A Refined Human Linear B Cell Epitope Map of Outer Surface Protein C (OspC) From the Lyme Disease Spirochete, Borrelia Burgdorferi

莱姆病螺旋体伯氏疏螺旋体外表面蛋白C (OspC) 的精细化人类线性B细胞表位图谱

Freeman-Gallant, Grace; McCarthy, Kathleen; Yates, Jennifer; Kulas, Karen; Rudolph, Michael J; Vance, David J; Mantis, Nicholas J