日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.

破坏 FUS 朊病毒样结构域中的 β 折叠可以保持相分离和功能,但可以防止聚集和毒性。

Wake Noah, Alcalde Juan, Jutzi Daniel, Bajaj Anjali, Kour Sukhleen, Barai Mayur, Weng Shuo-Lin, Cummings Samara, Zheng Tongyin, Anderson Eric N, Wang Szu-Huan, Puterbaugh Ryan, Bosco Daryl A, Schuster Benjamin S, Mittal Jeetain, Pandey Udai Bhan, Ruepp Marc-David, Fawzi Nicolas L

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS

单细胞RNA测序揭示了FUS-ALS和TARDBP-ALS患者运动神经元中特有的早期线粒体功能障碍。

Christoph Schweingruber ,Jik Nijssen ,Jonas Mechtersheimer ,Stefan Reber ,Mélanie Lebœuf ,Niamh L O'Brien ,Irene Mei ,Erin Hedges ,Michaela Keuper ,Julio Aguila Benitez ,Vlad Radoi ,Martin Jastroch ,Marc-David Ruepp # ,Eva Hedlund #

CORUM in 2024: protein complexes as drug targets

CORUM 2024:蛋白质复合物作为药物靶点

Steinkamp, Ralph; Tsitsiridis, George; Brauner, Barbara; Montrone, Corinna; Fobo, Gisela; Frishman, Goar; Avram, Sorin; Oprea, Tudor I; Ruepp, Andreas

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS

在肌萎缩侧索硬化症(ALS)中,一种具有降低的相分离潜能的胞质SFPQ亚型表达上调。

Jacob Neeves,Marija Petrić Howe,Oliver J Ziff,Beth Callaghan,Daniel Jutzi,Koustav Pal,Theodoros I Roumeliotis,Jyoti Choudhary,Adrian M Isaacs,Frank Rigo,C Frank Bennett,Marc-David Ruepp,Rickie Patani

Changes to the use of medicines containing the antibiotic azithromycin

含有抗生素阿奇霉素的药物使用方法发生变化

Ruepp, Robin; Botgros, Radu; Le Ber, Veronique; Brandt, Franziska; Pantke, Ellen; Fuerst-Wilmes, Miriam; Gomez-Outes, Antonio; Fernandez-Cortizo, Maria Jesus

Analysing the effect of full-length and C-terminally truncated progranulin on proliferation, colony formation, and migration in HepG2 and U87 cells

分析全长和C端截短的颗粒蛋白前体对HepG2和U87细胞增殖、克隆形成和迁移的影响

Alexander M Hofer ,Luisa Tobler ,Marc-David Ruepp ,Oliver Mühlemann

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD

构建C9orf72重复基因敲入的iPSC细胞系用于ALS和FTD模型研究

Coneys, Rachel; Cammack, Alexander J; Nair, Remya R; Thompson, David; Mechtersheimer, Jonas; Carcolé, Mireia; Gupta, Yashica; Rech, Gabriel E; Flower, Michael; O'Brien, Niamh; Ruepp, Marc-David; Mizielinska, Sarah; Ducotterd, Fiona; Tabrizi, Sarah J; Fisher, Elizabeth M C; Cunningham, Thomas J; Ward, Michael; Skarnes, William C; Isaacs, Adrian M

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.

U7 小核 RNA 剪接转换疗法用于治疗肌萎缩侧索硬化症中的 STMN2 和 UNC13A。

Mehta Puja R, Solomon Tomas, Pickles Sarah, Harley Peter, Barioglio Michela, Schweingruber Christoph, Marrero-Gagliardi Alessandro, Gao Yujing, Mattedi Francesca, Barattucci Simone, Lin Lilian Tsai-Wei, Ryadnov Eugeni, Zanovello Matteo, Cammack Alexander J, Isaacs Adrian M, Burrone Juan, Shaw Christopher E, Keuss Matthew J, Petrucelli Leonard, Fratta Pietro, Ruepp Marc-David

The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

Dsc 泛素连接酶复合物识别跨膜降解物,从而降解高尔基体中的孤儿蛋白

Yannick Weyer #, Sinead I Schwabl #, Xuechen Tang #, Astha Purwar, Konstantin Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, Michael A Widerin, Veronika Niedrist, Noa J M Mutsters, Maria G Tettamanti, Sabine Weys, Bettina Sarg, Leopold Kremser, Klaus R Liedl, Oliver Schmidt, David Teis

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

G-四链体通过促进肝细胞中cccDNA的转录和相分离来控制乙型肝炎病毒的复制。

Giraud, Guillaume; Rodà, Mélanie; Huchon, Pélagie; Michelet, Maud; Maadadi, Sarah; Jutzi, Daniel; Montserret, Roland; Ruepp, Marc-David; Parent, Romain; Combet, Christophe; Zoulim, Fabien; Testoni, Barbara