Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development
发现 4-((3'R,4'S,5'R)-6″-氯-4'-(3-氯-2-氟苯基)-1'-乙基-2″-氧代二螺[环己烷-1,2'-吡咯烷-3',3″-吲哚]-5'-甲酰胺基)双环[2.2.2]辛烷-1-羧酸 (AA-115/APG-115)：一种具有口服活性的强效小鼠双微体 2 (MDM2) 抑制剂，目前正处于临床开发阶段
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6b01665
Angelo Aguilar, Jianfeng Lu, Liu Liu, Ding Du, Denzil Bernard, Donna McEachern, Sally Przybranowski, Xiaoqin Li, Ruijuan Luo, Bo Wen, Duxin Sun, Hengbang Wang, Jianfeng Wen, Guangfeng Wang, Yifan Zhai, Ming Guo, Dajun Yang, Shaomeng Wang
