日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis

Sanfetrinem,一种口服β-内酰胺类抗生素,被重新用于治疗结核病

Ramón-García, Santiago; González Del Río, Rubén; Arenaz-Callao, María Pilar; Boshoff, Helena I; Rullas, Joaquín; Anca, Sara; Cacho Izquierdo, Mónica; Porras de Francisco, Esther; Pérez Herrán, Esther; Santos-Villarejo, Angel; Mendoza-Losana, Alfonso; Ferrer-Bazaga, Santiago; Thompson, Charles J; Barros Aguirre, David; Bates, Robert H

Contribution of direct InhA inhibitors to novel drug regimens in a mouse model of tuberculosis

直接InhA抑制剂对结核病小鼠模型新型药物治疗方案的贡献

Encinas, Lourdes; Li, Si-Yang; Rullas-Trincado, Joaquin; Tasneen, Rokeya; Tyagi, Sandeep; Soni, Heena; Garcia-Perez, Adolfo; Lee, Jin; González Del Río, Rubén; De Mercado, Jaime; Sousa, Verónica; Sosič, Izidor; Gobec, Stanislav; Mendoza-Losana, Alfonso; Converse, Paul J; Mdluli, Khisi; Fotouhi, Nader; Barros-Aguirre, David; Nuermberger, Eric L

Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

口服替比培南-阿维巴坦对小鼠脓肿分枝杆菌肺部感染模型的疗效

Dereje A Negatu, Rubén González Del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S Ganapathy, Matthew D Zimmerman, Martin Gengenbacher, Véronique Dartois, Thomas Dick

Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

在交叉食蟹猴结核分枝杆菌感染模型中测定异烟肼、利福平、吡嗪酰胺和乙胺丁醇的药代动力学和药效学

Sibley, Laura; White, Andrew D; Sarfas, Charlotte; Gullick, Jennie; Gleeson, Fergus; Lanni, Faye; Clark, Simon; Rayner, Emma; Ferrer-Bazaga, Santiago; Ortega-Muro, Fatima; Alameda, Laura; Rullas, Joaquin; Sousa, Veronica; Martinez, Marisa; Angulo-Barturen, Inigo; Garcia, Adolfo; Vaquero, Juan José; Pertinez, Henry E; Davies, Geraint; Dennis, Mike; Williams, Ann; Sharpe, Sally

GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.

GSK2556286 是一种新型抗结核药物候选物,在体内有效,有可能缩短结核病疗程

Nuermberger Eric L, Martínez-Martínez Maria Santos, Sanz Olalla, Urones Beatriz, Esquivias Jorge, Soni Heena, Tasneen Rokeya, Tyagi Sandeep, Li Si-Yang, Converse Paul J, Boshoff Helena I, Robertson Gregory T, Besra Gurdyal S, Abrahams Katherine A, Upton Anna M, Mdluli Khisimuzi, Boyle Gary W, Turner Sam, Fotouhi Nader, Cammack Nicholas C, Siles Juan Miguel, Alonso Marta, Escribano Jaime, Lelievre Joel, Rullas-Trincado Joaquin, Pérez-Herrán Esther, Bates Robert H, Maher-Edwards Gareth, Barros David, Ballell Lluís, Jiménez Elena

Identification of β-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions

由制药公司和学术机构组成的联盟对抗结核分枝杆菌的β-内酰胺类抗生素进行鉴定

Gold, Ben; Zhang, Jun; Quezada, Landys Lopez; Roberts, Julia; Ling, Yan; Wood, Madeleine; Shinwari, Wasima; Goullieux, Laurent; Roubert, Christine; Fraisse, Laurent; Bacqué, Eric; Lagrange, Sophie; Filoche-Rommé, Bruno; Vieth, Michal; Hipskind, Philip A; Jungheim, Louis N; Aubé, Jeffrey; Scarry, Sarah M; McDonald, Stacey L; Li, Kelin; Perkowski, Andrew; Nguyen, Quyen; Dartois, Véronique; Zimmerman, Matthew; Olsen, David B; Young, Katherine; Bonnett, Shilah; Joerss, Douglas; Parish, Tanya; Boshoff, Helena I; Arora, Kriti; Barry, Clifton E 3rd; Guijarro, Laura; Anca, Sara; Rullas, Joaquín; Rodríguez-Salguero, Beatriz; Martínez-Martínez, Maria S; Porras-De Francisco, Esther; Cacho, Monica; Barros-Aguirre, David; Smith, Paul; Berthel, Steven J; Nathan, Carl; Bates, Robert H

First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment

首次人体研究及强效亮氨酰tRNA合成酶抑制剂GSK3036656早期杀菌活性预测,用于结核病治疗

Tenero, David; Derimanov, Geo; Carlton, Alex; Tonkyn, John; Davies, Matt; Cozens, Simon; Gresham, Stephanie; Gaudion, Alison; Puri, Adeep; Muliaditan, Morris; Rullas-Trincado, Joaquin; Mendoza-Losana, Alfonso; Skingsley, Andrew; Barros-Aguirre, David

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

鉴定出吗啉代噻吩类化合物作为新型结核分枝杆菌抑制剂,靶向QcrB基因

Cleghorn, Laura A T; Ray, Peter C; Odingo, Joshua; Kumar, Anuradha; Wescott, Heather; Korkegian, Aaron; Masquelin, Thierry; Lopez Moure, Abraham; Wilson, Caroline; Davis, Susan; Huggett, Margaret; Turner, Penelope; Smith, Alasdair; Epemolu, Ola; Zuccotto, Fabio; Riley, Jennifer; Scullion, Paul; Shishikura, Yoko; Ferguson, Liam; Rullas, Joaquin; Guijarro, Laura; Read, Kevin D; Green, Simon R; Hipskind, Phil; Parish, Tanya; Wyatt, Paul G

Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface

通过靶向亚基间界面抑制分枝杆菌色氨酸合酶

Katherine A Abrahams, Jonathan A G Cox, Klaus Fütterer, Joaquín Rullas, Fátima Ortega-Muro, Nicholas J Loman, Patrick J Moynihan, Esther Pérez-Herrán, Elena Jiménez, Jorge Esquivias, David Barros, Lluís Ballell, Carlos Alemparte, Gurdyal S Besra

Identification of KasA as the cellular target of an anti-tubercular scaffold

确定 KasA 为抗结核支架的细胞靶点

Katherine A Abrahams, Chun-Wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S Gurcha, Jonathan A G Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J