日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability

静电相互作用调节IgG1和IgG4P抗体的差异性聚集倾向,并为带电残基的替换提供信息,从而提高其开发性。

James T Heads ,Richard Lamb ,Sebastian Kelm ,Ralph Adams ,Peter Elliott ,Kerry Tyson ,Sarfaraj Topia ,Shauna West ,Ruodan Nan ,Alison Turner ,Alastair D G Lawson

Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

表位决定治疗性抗 Tau 抗体在人类阿尔茨海默氏症 Tau 功能测定中的疗效

Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell,

Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces

因子 H 的两种不同构象调节液相和细胞表面的离散补体结合功能

Amy J Osborne, Ruodan Nan, Ami Miller, Jayesh S Bhatt, Jayesh Gor, Stephen J Perkins

A revised mechanism for the activation of complement C3 to C3b: a molecular explanation of a disease-associated polymorphism

补体 C3 激活为 C3b 的修订机制:疾病相关多态性的分子解释

Elizabeth Rodriguez, Ruodan Nan, Keying Li, Jayesh Gor, Stephen J Perkins

Zinc binding to the Tyr402 and His402 allotypes of complement factor H: possible implications for age-related macular degeneration

锌与补体因子 H 的 Tyr402 和 His402 同种型结合:对年龄相关性黄斑变性的可能影响

Ruodan Nan, Irene Farabella, Felix F Schumacher, Ami Miller, Jayesh Gor, Andrew C R Martin, David T Jones, Imre Lengyel, Stephen J Perkins

Complement factor H binds at two independent sites to C-reactive protein in acute phase concentrations

补体因子 H 在急性期浓度下在两个独立位点与 C 反应蛋白结合

Azubuike I Okemefuna, Ruodan Nan, Ami Miller, Jayesh Gor, Stephen J Perkins