HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues
具有 P1 膦酸酯修饰的 HIV-1 蛋白酶抑制剂通过增加与活瓣残基的相互作用来保持对抗耐药变体的效力
期刊:European Journal of Medicinal Chemistry
影响因子:6
doi:10.1016/j.ejmech.2023.115501
Gordon J Lockbaum, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Desaboini Nageswara Rao, Ean Spielvogel, Sook-Kyung Lee, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali