Russ B Altman相关文献与解析，生知库 | 链接生命科学的每一步

The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11)

E2F4 转录抑制因子是结肠癌对伊立替康 (CPT-11) 产生耐药性的关键机制调节剂

doi:10.1101/2025.01.22.633435

Junichi Matsubara, Yong Fuga Li, Sanjay Koul, Junko Mukohyama, Luis E Valencia Salazar, Taichi Isobe, Dalong Qian, Michael F Clarke, Debashis Sahoo, Russ B Altman, Piero Dalerba8

Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases

综合分析突显了与神经精神疾病相关的功能性调控变异。

期刊:Nature Genetics

影响因子:31.7

doi:10.1038/s41588-023-01533-5

Margaret G Guo,David L Reynolds,Cheen E Ang,Yingfei Liu,Yang Zhao,Laura K H Donohue,Zurab Siprashvili,Xue Yang,Yongjin Yoo,Smarajit Mondal,Audrey Hong,Jessica Kain,Lindsey Meservey,Tania Fabo,Ibtihal Elfaki,Laura N Kellman,Nathan S Abell,Yash Pershad,Vafa Bayat,Payam Etminani,Mark Holodniy,Daniel H Geschwind,Stephen B Montgomery,Laramie E Duncan,Alexander E Urban,Russ B Altman,Marius Wernig,Paul A Khavari

A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease

线粒体内外铁钙信号揭示帕金森病的药物靶点

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2023.113544

Vinita Bharat, Aarooran S Durairaj, Roeland Vanhauwaert, Li Li, Colin M Muir, Sujyoti Chandra, Chulhwan S Kwak, Yann Le Guen, Pawan Nandakishore, Chung-Han Hsieh, Stefano E Rensi, Russ B Altman, Michael D Greicius, Liang Feng, Xinnan Wang

Integrative analysis of functional genomic screening and clinical data identifies a protective role for spironolactone in severe COVID-19

功能基因组筛查和临床数据的综合分析确定螺内酯在重症 COVID-19 中的保护作用

期刊:Cell Reports Methods

影响因子:4.3

doi:10.1016/j.crmeth.2023.100503

Henry C Cousins, Adrienne Sarah Kline, Chengkun Wang, Yuanhao Qu, James Zengel, Jan Carette, Mengdi Wang, Russ B Altman, Yuan Luo, Le Cong

A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation

介导细胞类型特异性基因调控的DNA基序组合的顺式调控词典

期刊:Cell Genomics

影响因子:11.1

doi:10.1016/j.xgen.2022.100191

Laura K H Donohue,Margaret G Guo,Yang Zhao,Namyoung Jung,Rose T Bussat,Daniel S Kim,Poornima H Neela,Laura N Kellman,Omar S Garcia,Robin M Meyers,Russ B Altman,Paul A Khavari

Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution

以单细胞分辨率绘制脂肪肝中的转录异质性和代谢网络

期刊:iScience

影响因子:4.6

doi:10.1016/j.isci.2022.105802

Laetitia Coassolo, Tianyun Liu, Yunshin Jung, Nikki P Taylor, Meng Zhao, Gregory W Charville, Silas Boye Nissen, Hannele Yki-Jarvinen, Russ B Altman, Katrin J Svensson

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency

OCTN2 变异的功能基因组学为肉碱转运蛋白缺乏症的蛋白质特异性变异效应预测因子提供信息

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:

doi:10.1073/pnas.2210247119

Megan L Koleske, Gregory McInnes, Julia E H Brown, Neil Thomas, Keino Hutchinson, Marcus Y Chin, Antoine Koehl, Michelle R Arkin, Avner Schlessinger, Renata C Gallagher, Yun S Song, Russ B Altman, Kathleen M Giacomini

信号转导

发表日期：2022

文献求助收藏

Predicting HLA class II antigen presentation through integrated deep learning

通过集成深度学习预测 HLA II 类抗原呈递

期刊:Nature Biotechnology

影响因子:33.1

doi:10.1038/s41587-019-0280-2

Binbin Chen, Michael S Khodadoust, Niclas Olsson, Lisa E Wagar, Ethan Fast, Chih Long Liu, Yagmur Muftuoglu, Brian J Sworder, Maximilian Diehn, Ronald Levy, Mark M Davis, Joshua E Elias, Russ B Altman, Ash A Alizadeh

信号转导

发表日期：2019

文献求助收藏

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

Retro-2 通过抑制 ASNA1 介导的 ER 靶向和尾锚定蛋白的插入来保护细胞免受蓖麻毒素的毒性

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.48434

David W Morgens #, Charlene Chan #, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik

Genetic association studies using disease liabilities from deep neural networks

利用深度神经网络进行疾病易感性的遗传关联研究

The E2F4 transcriptional repressor is a key mechanistic regulator of colon cancer resistance to irinotecan (CPT-11)

E2F4 转录抑制因子是结肠癌对伊立替康 (CPT-11) 产生耐药性的关键机制调节剂

Integrative analyses highlight functional regulatory variants associated with neuropsychiatric diseases

综合分析突显了与神经精神疾病相关的功能性调控变异。

A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson's disease

线粒体内外铁钙信号揭示帕金森病的药物靶点

Integrative analysis of functional genomic screening and clinical data identifies a protective role for spironolactone in severe COVID-19

功能基因组筛查和临床数据的综合分析确定螺内酯在重症 COVID-19 中的保护作用

A cis-regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation

介导细胞类型特异性基因调控的DNA基序组合的顺式调控词典

Mapping transcriptional heterogeneity and metabolic networks in fatty livers at single-cell resolution

以单细胞分辨率绘制脂肪肝中的转录异质性和代谢网络

Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency

OCTN2 变异的功能基因组学为肉碱转运蛋白缺乏症的蛋白质特异性变异效应预测因子提供信息

Predicting HLA class II antigen presentation through integrated deep learning

通过集成深度学习预测 HLA II 类抗原呈递

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

Retro-2 通过抑制 ASNA1 介导的 ER 靶向和尾锚定蛋白的插入来保护细胞免受蓖麻毒素的毒性