mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy
小鼠心脏中结节性硬化症复合体 2 的消融导致 mTOR 过度激活,从而通过自噬下调引起小线粒体数量增加,从而诱发心脏功能障碍
期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0152628
Manabu Taneike, Kazuhiko Nishida, Shigemiki Omiya, Elham Zarrinpashneh, Tomofumi Misaka, Rika Kitazume-Taneike, Ruth Austin, Minoru Takaoka, Osamu Yamaguchi, Michael J Gambello, Ajay M Shah, Kinya Otsu
信号转导
免疫
神经
多发性硬化症
WB
Autophagy
mTOR
Mouse