日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

一种新型的人类胎肺来源的肺泡类器官模型揭示了与间质性肺疾病相关的表面活性蛋白C成熟的机制。

Lim, Kyungtae; Rutherford, Eimear N; Delpiano, Livia; He, Peng; Lin, Weimin; Sun, Dawei; Van den Boomen, Dick J H; Edgar, James R; Bang, Jae Hak; Predeus, Alexander; Teichmann, Sarah A; Marioni, John C; Matesic, Lydia E; Lee, Joo-Hyeon; Lehner, Paul J; Marciniak, Stefan J; Rawlins, Emma L; Dickens, Jennifer A

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing.

肺泡类器官的内源基因编辑显示,致病变异体 SFTPC-I73T 的表达会破坏内体功能、上皮极性和伤口愈合

Rutherford Eimear N, Sun Dawei, Lim Kyungtae, Edgar James R, Matesic Lydia E, Marciniak Stefan J, Rawlins Emma L, Dickens Jennifer A