Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases.
通过优化衍生物或 EPI-X4 靶向 CXCL12/CXCR4 通路,可以保护软骨细胞功能,并为风湿性疾病提供一种新的治疗方法。
期刊:Arthritis Research & Therapy
影响因子:4.6
doi:10.1186/s13075-025-03691-9
Ruths Leonie, de Hesselle Hannah, HauÃner Felix, Albers Sofya, Harms Mirja, Freitag Tobias, Münch Jan, Riegger Jana
细胞生物学
XCL1
CXCL1
CXCR4
CXCL12
CXCL1