日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV

一项综合工程策略提高了针对HIV的近乎泛中和抗体的效力和可生产性。

Mohammad M Sajadi,Abdolrahim Abbasi,Zahra Rikhtegaran Tehrani,Christine Siska,Rutilio Clark,Woo Chi,Michael S Seaman,Dieter Mielke,Kshitij Wagh,Qingbo Liu,Taylor Jumpa,Randal R Ketchem,Dung N Nguyen,William D Tolbert,Brian G Pierce,Ben Atkinson,Derrick Deming,Megan Sprague,Andrew Asakawa,David Ferrer,Yasmin Dunn,Sarah Calvillo,Rui Yin,Johnathan D Guest,Bette Korber,Bryan T Mayer,Alicia H Sato,Xin Ouyang,Scott Foulke,Parham Habibzadeh,Maryam Karimi,Arash Aslanabadi,Mahsa Hojabri,Saman Saadat,Roza Zareidoodeji,Mateusz Kędzior,Edwin Pozharski,Alonso Heredia,Hegang Chen,David Montefiori,Guido Ferrari,Marzena Pazgier,George K Lewis,Joseph G Jardine,Paolo Lusso,Anthony DeVico

Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity

10-1074 bnAb 的框架突变可提高构象稳定性、可制造性和稳定性,同时保留完全中和活性

Bruce A Kerwin, Chelsey Bennett, Yan Brodsky, Rutilio Clark, J Alaina Floyd, Alison Gillespie, Bryan T Mayer, Megan McClure, Christine Siska, Michael S Seaman, Kelly E Seaton, Jeremy Shaver, Georgia D Tomaras, Nicole L Yates, Randal R Ketchem

A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism

一种利用静电导向机制制备单价双特异性异二聚体IgG抗体的新型抗体工程策略

Zhi Liu ,Esther C Leng ,Kannan Gunasekaran ,Martin Pentony ,Min Shen ,Monique Howard ,Janelle Stoops ,Kathy Manchulenko ,Vladimir Razinkov ,Hua Liu ,William Fanslow ,Zhonghua Hu ,Nancy Sun ,Haruki Hasegawa ,Rutilio Clark ,Ian N Foltz ,Wei Yan