Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity
鉴定 CDK4/6 抑制剂为小分子 NLRP3 炎症小体激活剂,可促进 IL-1β 分泌和 T 细胞佐剂活性
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00516
Weiss, Adam M; Lopez, Marcos A 2nd; Rosenberger, Matthew G; Kim, Jeremiah Y; Shen, Jingjing; Chen, Qing; Ung, Trevor; Ibeh, Udoka M; Knight, Hannah Riley; Rutledge, Nakisha S; Studnitzer, Bradley; Rowan, Stuart J; Esser-Kahn, Aaron P
CDK4
炎症
T细胞
炎症/感染
LRP3
NLRP3
IL-1β
细胞生物学
炎性小体
免疫/内分泌