日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Enhancer Hijacking Discovery in Acute Myeloid Leukemia by Pyjacker Identifies MNX1 Activation via Deletion 7q

利用 Pyjacker 在急性髓系白血病中发现增强子劫持,揭示了 7q 缺失导致的 MNX1 激活。

Etienne Sollier #,Anna Riedel #,Umut H Toprak #,Justyna A Wierzbinska,Dieter Weichenhan,Jan Philipp Schmid,Mariam Hakobyan,Aurore Touzart,Ekaterina Jahn,Binje Vick,Fiona Brown-Burke,Katherine Kelly,Simge Kelekçi,Anastasija Pejkovska,Ashish Goyal,Marion Bähr,Kersten Breuer,Mei-Ju May Chen,Maria Llamazares-Prada,Mark Hartmann,Maximilian Schönung,Nadia Correia,Andreas Trumpp,Yomn Abdullah,Ursula Klingmüller,Sadaf S Mughal,Benedikt Brors,Frank Westermann,Elias Ulrich,Robert J Autry,Matthias Schlesner,Sebastian Vosberg,Tobias Herold,Philipp A Greif,Dietmar Pfeifer,Michael Lübbert,Thomas Fischer,Florian H Heidel,Claudia Gebhard,Wencke Walter,Torsten Haferlach,Ann-Kathrin Eisfeld,Krzysztof Mrózek,Deedra Nicolet,Lars Bullinger,Leonie Smeenk,Claudia Erpelinck-Verschueren,Roger Mulet-Lazaro,Ruud Delwel,Aurélie Ernst,Michael Scherer,Pavlo Lutsik,Irmela Jeremias,Konstanze Döhner,Hartmut Döhner,Daniel B Lipka #,Christoph Plass #

Oncogene EVI1 drives acute myeloid leukemia via a targetable interaction with CTBP2

癌基因 EVI1 通过与 CTBP2 的可靶向相互作用驱动急性髓系白血病。

Dorien Pastoors ,Marije Havermans ,Roger Mulet-Lazaro ,Duncan Brian ,Willy Noort ,Julius Grasel ,Remco Hoogenboezem ,Leonie Smeenk ,Jeroen A A Demmers ,Michael D Milsom ,Tariq Enver ,Richard W J Groen ,Eric Bindels ,Ruud Delwel

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia

CEBPA双突变急性髓系白血病基因调控网络的鉴定与探究

Assunta Adamo #, Paulynn Chin #, Peter Keane, Salam A Assi, Sandeep Potluri, Sophie G Kellaway, Daniel Coleman, Luke Ames, Anetta Ptasinska, H Ruud Delwel, Peter N Cockerill, Constanze Bonifer

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia

白血病中易位增强子致癌性过度激活对MYB的选择性需求

Leonie Smeenk ,Sophie Ottema ,Roger Mulet-Lazaro ,Anja Ebert ,Marije Havermans ,Andrea Arricibita Varea ,Michaela Fellner ,Dorien Pastoors ,Stanley van Herk ,Claudia Erpelinck-Verschueren ,Tim Grob ,Remco M Hoogenboezem ,François G Kavelaars ,Daniel R Matson ,Emery H Bresnick ,Eric M Bindels ,Alex Kentsis ,Johannes Zuber # ,Ruud Delwel #

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

BCL6 维持原代人类急性髓系白血病细胞的生存和自我更新

Kimihito C Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E Mason, Ari Melnick, Monica L Guzman

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops

白血病致癌基因 EVI1 通过 CTCF 促进的环路劫持 MYC 超级增强子

Sophie Ottema #, Roger Mulet-Lazaro #, Claudia Erpelinck-Verschueren #, Stanley van Herk, Marije Havermans, Andrea Arricibita Varea, Michael Vermeulen, H Berna Beverloo, Stefan Gröschel, Torsten Haferlach, Claudia Haferlach, Bas J Wouters, Eric Bindels, Leonie Smeenk, Ruud Delwel

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

通过抑制蛋白质精氨酸甲基化来靶向RNA剪接催化进行治疗

Jia Yi Fong,Luca Pignata,Pierre-Alexis Goy,Kimihito Cojin Kawabata,Stanley Chun-Wei Lee,Cheryl M Koh,Daniele Musiani,Enrico Massignani,Andriana G Kotini,Alex Penson,Cheng Mun Wun,Yudao Shen,Megan Schwarz,Diana Hp Low,Alexander Rialdi,Michelle Ki,Heike Wollmann,Slim Mzoughi,Florence Gay,Christine Thompson,Timothy Hart,Olena Barbash,Genna M Luciani,Magdalena M Szewczyk,Bas J Wouters,Ruud Delwel,Eirini P Papapetrou,Dalia Barsyte-Lovejoy,Cheryl H Arrowsmith,Mark D Minden,Jian Jin,Ari Melnick,Tiziana Bonaldi,Omar Abdel-Wahab,Ernesto Guccione

Subtype-specific regulatory network rewiring in acute myeloid leukemia

急性髓系白血病中亚型特异性调控网络重构

Salam A Assi #, Maria Rosaria Imperato #, Daniel J L Coleman #, Anna Pickin, Sandeep Potluri, Anetta Ptasinska, Paulynn Suyin Chin, Helen Blair, Pierre Cauchy, Sally R James, Joaquin Zacarias-Cabeza, L Niall Gilding, Andrew Beggs, Sam Clokie, Justin C Loke, Phil Jenkin, Ash Uddin, Ruud Delwel, Steph

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

t(8;21) AML 中 RUNX1-ETO 的缺失导致 C/EBPα 和 AP-1 介导的增强子-启动子相互作用改变

Anetta Ptasinska ,Anna Pickin ,Salam A Assi ,Paulynn Suyin Chin ,Luke Ames ,Roberto Avellino ,Stefan Gröschel ,Ruud Delwel ,Peter N Cockerill ,Cameron S Osborne ,Constanze Bonifer

Temporal autoregulation during human PU.1 locus SubTAD formation

人类 PU.1 基因座 SubTAD 形成过程中的时间自动调节

Daniel Schuetzmann, Carolin Walter, Boet van Riel, Sabrina Kruse, Thorsten König, Tabea Erdmann, Alexander Tönges, Eric Bindels, Andre Weilemann, Claudia Gebhard, Klaus Wethmar, Chiara Perrod, Julia Minderjahn, Michael Rehli, Ruud Delwel, Georg Lenz, Stefan Gröschel, Martin Dugas, Frank Rosenbauer