日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts.

AML获得性多药耐药是由复发性髓母细胞凋亡启动不足引起的

Olesinski Elyse A, Bhatia Karanpreet Singh, Wang Chuqi, Pioso Marissa S, Lin Xiao Xian, Mamdouh Ahmed M, Ng Shu Xuan, Sandhu Vedant, Jasdanwala Shaista Shabbir, Yilma Binyam, Bohl Stephan, Ryan Jeremy A, Malani Disha, Luskin Marlise R, Kallioniemi Olli, Porkka Kimmo, Adamia Sophia, Chng Wee Joo, Osato Motomi, Weinstock David M, Garcia Jacqueline S, Letai Anthony, Bhatt Shruti

Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

更正:RAS/MAPK通路激活赋予急性髓系白血病细胞MCL-1介导的对BCL-2抑制剂维奈托克的获得性耐药性。

Zhang, Qi; Riley-Gillis, Bridget; Han, Lina; Jia, Yannan; Lodi, Alessia; Zhang, Haijiao; Ganesan, Saravanan; Pan, Rongqing; Konoplev, Sergej N; Sweeney, Shannon R; Ryan, Jeremy A; Jitkova, Yulia; Dunner, Kenneth Jr; Grosskurth, Shaun E; Vijay, Priyanka; Ghosh, Sujana; Lu, Charles; Ma, Wencai; Kurtz, Stephen; Ruvolo, Vivian R; Ma, Helen; Weng, Connie C; Ramage, Cassandra L; Baran, Natalia; Shi, Ce; Cai, Tianyu; Davis, Richard Eric; Battula, Venkata L; Mi, Yingchang; Wang, Jing; DiNardo, Courtney D; Andreeff, Michael; Tyner, Jeffery W; Schimmer, Aaron; Letai, Anthony; Padua, Rose Ann; Bueso-Ramos, Carlos E; Tiziani, Stefano; Leverson, Joel; Popovic, Relja; Konopleva, Marina

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

迭代优化法制备出靶向 Mcl-1 的交联肽,该肽对 Mcl-1 依赖性癌细胞具有选择性细胞毒性。

Rezaei Araghi, Raheleh; Bird, Gregory H; Ryan, Jeremy A; Jenson, Justin M; Godes, Marina; Pritz, Jonathan R; Grant, Robert A; Letai, Anthony; Walensky, Loren D; Keating, Amy E

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

c-Myc对线粒体凋亡的发育调控决定了癌症治疗的年龄和组织特异性敏感性

Sarosiek, Kristopher A; Fraser, Cameron; Muthalagu, Nathiya; Bhola, Patrick D; Chang, Weiting; McBrayer, Samuel K; Cantlon, Adam; Fisch, Sudeshna; Golomb-Mello, Gail; Ryan, Jeremy A; Deng, Jing; Jian, Brian; Corbett, Chris; Goldenberg, Marti; Madsen, Joseph R; Liao, Ronglih; Walsh, Dominic; Sedivy, John; Murphy, Daniel J; Carrasco, Daniel Ruben; Robinson, Shenandoah; Moslehi, Javid; Letai, Anthony

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

异种移植公共数据库促进了小鼠的发现和随机II期样试验

Townsend, Elizabeth C; Murakami, Mark A; Christodoulou, Alexandra; Christie, Amanda L; Köster, Johannes; DeSouza, Tiffany A; Morgan, Elizabeth A; Kallgren, Scott P; Liu, Huiyun; Wu, Shuo-Chieh; Plana, Olivia; Montero, Joan; Stevenson, Kristen E; Rao, Prakash; Vadhi, Raga; Andreeff, Michael; Armand, Philippe; Ballen, Karen K; Barzaghi-Rinaudo, Patrizia; Cahill, Sarah; Clark, Rachael A; Cooke, Vesselina G; Davids, Matthew S; DeAngelo, Daniel J; Dorfman, David M; Eaton, Hilary; Ebert, Benjamin L; Etchin, Julia; Firestone, Brant; Fisher, David C; Freedman, Arnold S; Galinsky, Ilene A; Gao, Hui; Garcia, Jacqueline S; Garnache-Ottou, Francine; Graubert, Timothy A; Gutierrez, Alejandro; Halilovic, Ensar; Harris, Marian H; Herbert, Zachary T; Horwitz, Steven M; Inghirami, Giorgio; Intlekofer, Andrew M; Ito, Moriko; Izraeli, Shai; Jacobsen, Eric D; Jacobson, Caron A; Jeay, Sébastien; Jeremias, Irmela; Kelliher, Michelle A; Koch, Raphael; Konopleva, Marina; Kopp, Nadja; Kornblau, Steven M; Kung, Andrew L; Kupper, Thomas S; LeBoeuf, Nicole R; LaCasce, Ann S; Lees, Emma; Li, Loretta S; Look, A Thomas; Murakami, Masato; Muschen, Markus; Neuberg, Donna; Ng, Samuel Y; Odejide, Oreofe O; Orkin, Stuart H; Paquette, Rachel R; Place, Andrew E; Roderick, Justine E; Ryan, Jeremy A; Sallan, Stephen E; Shoji, Brent; Silverman, Lewis B; Soiffer, Robert J; Steensma, David P; Stegmaier, Kimberly; Stone, Richard M; Tamburini, Jerome; Thorner, Aaron R; van Hummelen, Paul; Wadleigh, Martha; Wiesmann, Marion; Weng, Andrew P; Wuerthner, Jens U; Williams, David A; Wollison, Bruce M; Lane, Andrew A; Letai, Anthony; Bertagnolli, Monica M; Ritz, Jerome; Brown, Myles; Long, Henry; Aster, Jon C; Shipp, Margaret A; Griffin, James D; Weinstock, David M

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains

利用包含非天然侧链的交联肽库快速优化Mcl-1抑制剂

Rezaei Araghi, Raheleh; Ryan, Jeremy A; Letai, Anthony; Keating, Amy E

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells

设计具有高亲和力和特异性的BH3肽,用于靶向细胞中的Mcl-1。

Foight, Glenna Wink; Ryan, Jeremy A; Gullá, Stefano V; Letai, Anthony; Keating, Amy E

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis

高线粒体启动水平使人胚胎干细胞对DNA损伤诱导的细胞凋亡更加敏感

Liu, Julia C; Guan, Xiao; Ryan, Jeremy A; Rivera, Ana G; Mock, Caroline; Agrawal, Vishesh; Letai, Anthony; Lerou, Paul H; Lahav, Galit