日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity

EP3 拮抗剂 DG-041 对饮食诱导性肥胖雄性小鼠的影响

Ryan P Ceddia, Jason D Downey, Ryan D Morrison, Maria P Kraemer, Sarah E Davis, Jing Wu, Craig W Lindsley, Huiyong Yin, J Scott Daniels, Richard M Breyer

In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate

2-羟基苄胺醋酸盐体外安全药理学评价

John C Fuller Jr, Lisa M Pitchford, Ryan D Morrison, J Scott Daniels, Charles R Flynn, Naji N Abumrad, John A Oates, Olivier Boutaud, John A Rathmacher

Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity

评估 P450 活性减弱的大鼠体内混合醛氧化酶/细胞色素 P450 底物的分布

Rachel D Crouch, Ryan D Morrison, Frank W Byers, Craig W Lindsley, Kyle A Emmitte, J Scott Daniels

Lack of Antiparkinsonian Effects of Systemic Injections of the Specific T-Type Calcium Channel Blocker ML218 in MPTP-Treated Monkeys

在接受 MPTP 治疗的猴子中,全身注射特定 T 型钙通道阻滞剂 ML218 缺乏抗帕金森病作用

Adriana Galvan, Annaelle Devergnas, Damien Pittard, Gunasingh Masilamoni, Jocelyn Vuong, J Scott Daniels, Ryan D Morrison, Craig W Lindsley, Thomas Wichmann

VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy

VU0477573:具有体内功效的亚型 5 代谢型谷氨酸受体的部分负变构调节剂

Hilary Highfield Nickols, Joannes P Yuh, Karen J Gregory, Ryan D Morrison, Brittney S Bates, Shaun R Stauffer, Kyle A Emmitte, Michael Bubser, Weimin Peng, Michael T Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J Scott Daniels, Colleen M Niswender, Craig W Lindsley, Carrie K Jones, P Jeff

ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice

ML297 (VU0456810) 是第一种有效且选择性的 GIRK 钾通道激活剂,在小鼠中表现出抗癫痫特性

Kristian Kaufmann, Ian Romaine, Emily Days, Conrado Pascual, Adam Malik, Liya Yang, Bende Zou, Yu Du, Greg Sliwoski, Ryan D Morrison, Jerod Denton, Colleen M Niswender, J Scott Daniels, Gary A Sulikowski, Xinmin Simon Xie, Craig W Lindsley, C David Weaver

Enzymatic conversion of 6-nitroquinoline to the fluorophore 6-aminoquinoline selectively under hypoxic conditions

低氧条件下 6-硝基喹啉选择性酶促转化为荧光团 6-氨基喹啉

Anuruddha Rajapakse, Collette Linder, Ryan D Morrison, Ujjal Sarkar, Nathan D Leigh, Charles L Barnes, J Scott Daniels, Kent S Gates

N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats

N-酰基-N'-芳基哌嗪作为 mGlu1 的负变构调节剂:鉴定 VU0469650,一种在大鼠中枢神经系统中具有暴露作用的强效选择性工具化合物

Kimberly M Lovell, Andrew S Felts, Alice L Rodriguez, Daryl F Venable, Hyekyung P Cho, Ryan D Morrison, Frank W Byers, J Scott Daniels, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Kyle A Emmitte

Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe

进一步优化 K-Cl 同向转运蛋白 KCC2 拮抗剂 ML077:开发一种高选择性、更有效的体外探针

Eric Delpire, Aleksandra Baranczak, Alex G Waterson, Kwangho Kim, Nathan Kett, Ryan D Morrison, J Scott Daniels, C David Weaver, Craig W Lindsley