日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins

亨廷顿蛋白含有泛素结合域，可调节线粒体和 RNA 结合蛋白的溶酶体靶向性

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2319091121
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Lesl
细胞生物学
发表日期：2024
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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

从ALS患者和对照组受试者中大规模分化iPSC衍生的运动神经元

期刊:Neuron
影响因子:14.7
doi:10.1016/j.neuron.2023.01.010
Michael J Workman ，Ryan G Lim ，Jie Wu ，Aaron Frank ，Loren Ornelas ，Lindsay Panther ，Erick Galvez ，Daniel Perez ，Imara Meepe ，Susan Lei ，Viviana Valencia ，Emilda Gomez ，Chunyan Liu ，Ruby Moran ，Louis Pinedo ，Stanislav Tsitkov ，Ritchie Ho ，Julia A Kaye ，Jeffrey D Rothstein ，Steven Finkbeiner ，Ernest Fraenkel ，Dhruv Sareen ，Leslie M Thompson ，Clive N Svendsen
ALS
神经科学
发表日期：2023
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Transplanted human neural stem cells rescue phenotypes in zQ175 Huntington's disease mice and innervate the striatum

移植的人类神经干细胞可挽救zQ175亨廷顿病小鼠的表型并支配纹状体。

期刊:Molecular Therapy
影响因子:12.1
doi:10.1016/j.ymthe.2023.10.003
Sandra M Holley,Jack C Reidling,Carlos Cepeda,Jie Wu,Ryan G Lim,Alice Lau,Cindy Moore,Ricardo Miramontes,Brian Fury,Iliana Orellana,Michael Neel,Dane Coleal-Bergum,Edwin S Monuki,Gerhard Bauer,Charles K Meshul,Michael S Levine,Leslie M Thompson
Human
细胞生物学
神经科学
发育与干细胞
干细胞
发表日期：2023
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An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells

改变的细胞外基质-整合素界面导致亨廷顿氏病相关的神经胶质细胞和血管细胞中枢神经系统功能障碍

期刊:Human Molecular Genetics
影响因子:3.1
doi:10.1093/hmg/ddac303
Sarah J Hernandez, Ryan G Lim, Tarik Onur, Mark A Dane, Rebecca Smith, Keona Wang, Grace En-Hway Jean, Andrea Reyes-Ortiz, Kaylyn Devlin, Ricardo Miramontes, Jie Wu, Malcolm Casale, David Kilburn, Laura M Heiser, James E Korkola, David Van Vactor, Juan Botas, Katherine L Thompson-Peer, Leslie M Thom
神经
胶质细胞
发表日期：2023
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Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Answer ALS 是散发性和家族性 ALS 的大规模资源，结合了诱导性多能细胞系的临床和多组学数据

期刊:Nature Neuroscience
影响因子:21.2
doi:10.1038/s41593-021-01006-0
Emily G Baxi, Terri Thompson, Jonathan Li, Julia A Kaye, Ryan G Lim, Jie Wu, Divya Ramamoorthy, Leandro Lima, Vineet Vaibhav, Andrea Matlock, Aaron Frank, Alyssa N Coyne, Barry Landin, Loren Ornelas, Elizabeth Mosmiller, Sara Thrower, S Michelle Farr, Lindsey Panther, Emilda Gomez, Erick Galvez, Dan
免疫
细胞生物学
其它细胞
发表日期：2022
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Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation

单核 RNA 测序显示亨廷顿病少突胶质细胞成熟缺陷可通过补充硫胺素-生物素来挽救

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-022-35388-x
Ryan G Lim #, Osama Al-Dalahmah #, Jie Wu #, Maxwell P Gold, Jack C Reidling, Guomei Tang, Miriam Adam, David K Dansu, Hye-Jin Park, Patrizia Casaccia, Ricardo Miramontes, Andrea M Reyes-Ortiz, Alice Lau, Richard A Hickman, Fatima Khan, Fahad Paryani, Alice Tang, Kenneth Ofori, Emily Miyoshi, Neethu
细胞生物学
胶质细胞
IHC
Donkey
IgG
发表日期：2022
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Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits

亨廷顿病 iPSC 和小鼠星形胶质细胞的单核转录组分析表明成熟和功能缺陷

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2022.105732
Andrea M Reyes-Ortiz, Edsel M Abud, Mara S Burns, Jie Wu, Sarah J Hernandez, Nicolette McClure, Keona Q Wang, Corey J Schulz, Ricardo Miramontes, Alice Lau, Neethu Michael, Emily Miyoshi, David Van Vactor, John C Reidling, Mathew Blurton-Jones, Vivek Swarup, Wayne W Poon, Ryan G Lim, Leslie M Thomps
细胞生物学
胶质细胞
Mouse
发表日期：2022
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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

C9ORF72 ALS 患者 iPSC 衍生运动神经元的综合多组学分析

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2021.103221
NeuroLINCS Consortium; Jonathan Li, Ryan G Lim, Julia A Kaye, Victoria Dardov, Alyssa N Coyne, Jie Wu, Pamela Milani, Andrew Cheng, Terri G Thompson, Loren Ornelas, Aaron Frank, Miriam Adam, Maria G Banuelos, Malcolm Casale, Veerle Cox, Renan Escalante-Chong, J Gavin Daigle, Emilda Gomez, Lindsey Ha
神经
发表日期：2021
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PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease

PIAS1 调节纹状体转录、DNA 损伤修复和 SUMO 化，与亨廷顿氏病相关

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:
doi:10.1073/pnas.2021836118
Eva L Morozko, Charlene Smith-Geater, Alejandro Mas Monteys, Subrata Pradhan, Ryan G Lim, Peter Langfelder, Marketta Kachemov, Jayesh A Kulkarni, Josh Zaifman, Austin Hill, Jennifer T Stocksdale, Pieter R Cullis, Jie Wu, Joseph Ochaba, Ricardo Miramontes, Anirban Chakraborty, Tapas K Hazra, Alice La
信号转导
发表日期：2021
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Aberrant Development Corrected in Adult-Onset Huntington's Disease iPSC-Derived Neuronal Cultures via WNT Signaling Modulation

通过 WNT 信号调节纠正成人亨廷顿舞蹈症 iPSC 衍生神经元培养中的异常发育

期刊:Stem Cell Reports
影响因子:5.9
doi:10.1016/j.stemcr.2020.01.015
Charlene Smith-Geater, Sarah J Hernandez, Ryan G Lim, Miriam Adam, Jie Wu, Jennifer T Stocksdale, Brook T Wassie, Maxwell Philip Gold, Keona Q Wang, Ricardo Miramontes, Lexi Kopan, Iliana Orellana, Shona Joy, Paul J Kemp, Nicholas D Allen, Ernest Fraenkel, Leslie M Thompson
神经
Wnt/β-Catenin
发表日期：2020
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