日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions

不同金属离子稳定的Aβ寡聚体的结构与神经毒性作用的关系

Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Michele Vendruscolo

Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

氨基甾醇对蛋白质聚集体的保护作用与其化学结构和调节生物膜的能力的定量归因

Silvia Errico, Giacomo Lucchesi, Davide Odino, Enass Youssef Osman, Roberta Cascella, Lorenzo Neri, Claudia Capitini, Martino Calamai, Francesco Bemporad, Cristina Cecchi, William A Kinney, Denise Barbut, Annalisa Relini, Claudio Canale, Gabriella Caminati, Ryan Limbocker, Michele Vendruscolo, Micha

Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation

维生素 A 和维生素 E 代谢物的组合可抵抗淀粉样β蛋白的聚集

Priyanka Joshi, Sean Chia, Xiaoting Yang, Michele Perni, Justus M Gabriel, Marshall Gilmer, Ryan Limbocker, Johnny Habchi, Michele Vendruscolo

Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response

两种人类代谢物通过细胞质未折叠蛋白反应拯救了秀丽隐杆线虫阿尔茨海默病模型

Priyanka Joshi, Michele Perni, Ryan Limbocker, Benedetta Mannini, Sam Casford, Sean Chia, Johnny Habchi, Johnathan Labbadia, Christopher M Dobson, Michele Vendruscolo

Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease

小分子封存淀粉样β蛋白作为阿尔茨海默病的药物研发策略

Gabriella T Heller, Francesco A Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Michele Vend

A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease

合理设计的双环肽可在体外重塑 Aβ42 聚集并降低其在阿尔茨海默病蠕虫模型中的毒性

Tatsuya Ikenoue, Francesco A Aprile, Pietro Sormanni, Francesco S Ruggeri, Michele Perni, Gabriella T Heller, Christian P Haas, Christoph Middel, Ryan Limbocker, Benedetta Mannini, Thomas C T Michaels, Tuomas P J Knowles, Christopher M Dobson, Michele Vendruscolo

Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers

合理设计的抗体作为研究工具,用于研究β-淀粉样蛋白寡聚体的结构-毒性关系

Ryan Limbocker ,Benedetta Mannini ,Rodrigo Cataldi ,Shianne Chhangur ,Aidan K Wright ,Ryan P Kreiser ,J Alex Albright ,Sean Chia ,Johnny Habchi ,Pietro Sormanni ,Janet R Kumita ,Francesco S Ruggeri ,Christopher M Dobson ,Fabrizio Chiti ,Francesco A Aprile ,Michele Vendruscolo

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

合理设计用于定量 Aβ 寡聚体的构象特异性抗体

Francesco A Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur, Lisa-Maria Needham, Francesco S Ruggeri, Michele Perni, Ryan Limbocker, Gabriella T Heller, Tomas Sneideris, Tom Scheidt, Benedetta Mannini, Johnny Habchi, Steven F Lee, Patricia C Salinas, Tuomas P J Knowles, Christopher M Dobs

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

Trodusquemine 能增强 Aβ42 的聚集,但通过将寡聚体从细胞膜上置换下来抑制其毒性。

Ryan Limbocker ,Sean Chia ,Francesco S Ruggeri ,Michele Perni ,Roberta Cascella ,Gabriella T Heller ,Georg Meisl ,Benedetta Mannini ,Johnny Habchi ,Thomas C T Michaels ,Pavan K Challa ,Minkoo Ahn ,Samuel T Casford ,Nilumi Fernando ,Catherine K Xu ,Nina D Kloss ,Samuel I A Cohen ,Janet R Kumita ,Cristina Cecchi ,Michael Zasloff ,Sara Linse ,Tuomas P J Knowles ,Fabrizio Chiti ,Michele Vendruscolo ,Christopher M Dobson