日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis

执行者胱天蛋白酶在化疗诱导的细胞凋亡过程中限制线粒体 RNA 驱动的 I 型干扰素诱导

Shane T Killarney, Rachel Washart, Ryan S Soderquist, Jacob P Hoj, Jamie Lebhar, Kevin H Lin, Kris C Wood

Small-molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells

小分子靶向治疗诱导残留肿瘤细胞对 DNA 双链断裂修复的依赖

Moiez Ali, Min Lu, Hazel Xiaohui Ang, Ryan S Soderquist, Christine E Eyler, Haley M Hutchinson, Carolyn Glass, Christopher F Bassil, Omar M Lopez, D Lucas Kerr, Christina J Falcon, Helena A Yu, Aaron N Hata, Collin M Blakely, Caroline E McCoach, Trever G Bivona, Kris C Wood

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity

对 AML 中代谢-凋亡界面的系统解剖表明血红素生物合成是药物敏感性的调节剂

Kevin H Lin, Abigail Xie, Justine C Rutter, Yeong-Ran Ahn, Julia M Lloyd-Cowden, Amanda G Nichols, Ryan S Soderquist, Timothy R Koves, Deborah M Muoio, Nancie J MacIver, Jatinder K Lamba, Timothy S Pardee, Chad M McCall, David A Rizzieri, Kris C Wood

Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models

基因组学小分子药物克服了患者源性肿瘤模型中对缓释工程死亡受体激动剂的耐药性

Mandana T Manzari, Gray R Anderson, Kevin H Lin, Ryan S Soderquist, Merve Çakir, Mitchell Zhang, Chandler E Moore, Rachel N Skelton, Maréva Fèvre, Xinghai Li, Joseph J Bellucci, Suzanne E Wardell, Simone A Costa, Kris C Wood, Ashutosh Chilkoti

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477

常用浓度的 BH3 类似物的混杂脱靶效应:MIM1、UMI-77 和 A-1210477

David J Mallick, Ryan S Soderquist, Darcy Bates, Alan Eastman

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

癌症中 BCL-2 基因依赖性的系统映射揭示了 BH3 模拟敏感性的分子决定因素

Ryan S Soderquist, Lorin Crawford, Esther Liu, Min Lu, Anika Agarwal, Gray R Anderson, Kevin H Lin, Peter S Winter, Merve Cakir, Kris C Wood

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

KRAS 突变癌症的治疗协同性概况揭示了控制肿瘤进化的原理

Grace R Anderson, Peter S Winter, Kevin H Lin, Daniel P Nussbaum, Merve Cakir, Elizabeth M Stein, Ryan S Soderquist, Lorin Crawford, Jim C Leeds, Rachel Newcomb, Priya Stepp, Catherine Yip, Suzanne E Wardell, Jennifer P Tingley, Moiez Ali, Mengmeng Xu, Meagan Ryan, Shannon J McCall, Autumn J McRee, 

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

细胞周期蛋白依赖性激酶抑制剂 P1446A 以 JNK/p38 MAPK 依赖的方式诱导慢性淋巴细胞白血病 B 细胞凋亡

Cody Paiva, J Claire Godbersen, Ryan S Soderquist, Taylor Rowland, Sumner Kilmarx, Stephen E Spurgeon, Jennifer R Brown, Sreesha P Srinivasa, Alexey V Danilov

Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress

棉酚通过一种涉及磷脂酶 A2、细胞质钙和内质网应激的新机制增加促凋亡的 BH3 特异性蛋白 NOXA 的表达

Ryan S Soderquist, Alexey V Danilov, Alan Eastman