Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent
合成以4'-氰基-6''-氟亚甲基环戊烯骨架为苷元部分的新型恩替卡韦类似物,该类似物是一种高效长效的抗乙型肝炎病毒药物。
期刊:RSC Advances
影响因子:4.6
doi:10.1039/d3ra01750h
Kumamoto, Hiroki; Higashi-Kuwata, Nobuyo; Hayashi, Sanae; Das, Debananda; Bulut, Haydar; Tokuda, Ryoh; Imoto, Shuhei; Onitsuka, Kengo; Honda, Yuka; Odanaka, Yuki; Shimbara-Matsubayashi, Satoko; Haraguchi, Kazuhiro; Tanaka, Yasuhito; Mitsuya, Hiroaki