日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15

不同的TAF15淀粉样蛋白丝折叠定义了FTLD-TAF15的多种亚型

Tetter, Stephan; Varghese, Nikhil R; Murzin, Alexey G; De Coster, Wouter; Van den Broeck, Marleen; Roeber, Sigrun; Joseph, Jeffrey T; Newell, Kathy; Castellani, Rudolf; Das, Sumit; Ang, Lee-Cyn; Synofzik, Matthis; Herms, Jochen; Rademakers, Rosa; Ghetti, Bernardino; Lashley, Tammaryn; Mackenzie, Ian R A; Neumann, Manuela; Ryskeldi-Falcon, Benjamin

Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction.

病理性 TDP-43 丝状物在突触处积聚,导致突触功能障碍。

Chen Renren, Stockwell Imogen, Pierce Jessica C, Peak-Chew Sew-Yeu, Huang Melissa, Newell Kathy, Ghetti Bernardino, Cousin Michael A, Greger Ingo H, Ryskeldi-Falcon Benjamin

Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2.

人类神经元对 Tau 蛋白的摄取依赖于受体 LRP1 和激酶 LRRK2

Evans Lewis D, Strano Alessio, Tuck Eleanor, Campbell Ashley, Smith James, Hung Christy, Behr Tiana S, Ghetti Bernardino, Ryskeldi-Falcon Benjamin, Karakoc Emre, Iorio Francesco, Reith Alastair, Bassett Andrew R, Livesey Frederick J

Seeding biosensor cell line that reproduces the Alzheimer tau fold.

建立能够重现阿尔茨海默病 tau 折叠的生物传感器细胞系。

Katsinelos Taxiarchis, Lövestam Sofia, Qi Chao, Ryskeldi-Falcon Benjamin, Macdonald Jennifer A, Stephenson Gabriel, Ghetti Bernardino, McKee Ann, Scheres Sjors H W, Goedert Michel

Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold

肌萎缩侧索硬化症/帕金森病-痴呆综合征中的tau蛋白丝呈现出CTE折叠结构。

Qi, Chao; Verheijen, Bert M; Kokubo, Yasumasa; Shi, Yang; Tetter, Stephan; Murzin, Alexey G; Nakahara, Asa; Morimoto, Satoru; Vermulst, Marc; Sasaki, Ryogen; Aronica, Eleonora; Hirokawa, Yoshifumi; Oyanagi, Kiyomitsu; Kakita, Akiyoshi; Ryskeldi-Falcon, Benjamin; Yoshida, Mari; Hasegawa, Masato; Scheres, Sjors H W; Goedert, Michel

Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold

肌萎缩侧索硬化症/帕金森病-痴呆综合征 (ALS/PDC) 中的 tau 丝形成 CTE 折叠

Qi, Chao; Verheijen, Bert M; Kokubo, Yasumasa; Shi, Yang; Tetter, Stephan; Murzin, Alexey G; Nakahara, Asa; Morimoto, Satoru; Vermulst, Marc; Sasaki, Ryogen; Aronica, Eleonora; Hirokawa, Yoshifumi; Oyanagi, Kiyomitsu; Kakita, Akiyoshi; Ryskeldi-Falcon, Benjamin; Yoshida, Mari; Hasegawa, Masato; Scheres, Sjors H W; Goedert, Michel

Structure of pathological TDP-43 filaments from ALS with FTLD

肌萎缩侧索硬化症伴额颞叶痴呆症中病理性TDP-43丝的结构

Arseni, Diana; Hasegawa, Masato; Murzin, Alexey G; Kametani, Fuyuki; Arai, Makoto; Yoshida, Mari; Ryskeldi-Falcon, Benjamin

Age-dependent formation of TMEM106B amyloid filaments in human brains

人类大脑中TMEM106B淀粉样蛋白丝的形成与年龄相关

Schweighauser, Manuel; Arseni, Diana; Bacioglu, Mehtap; Huang, Melissa; Lövestam, Sofia; Shi, Yang; Yang, Yang; Zhang, Wenjuan; Kotecha, Abhay; Garringer, Holly J; Vidal, Ruben; Hallinan, Grace I; Newell, Kathy L; Tarutani, Airi; Murayama, Shigeo; Miyazaki, Masayuki; Saito, Yuko; Yoshida, Mari; Hasegawa, Kazuko; Lashley, Tammaryn; Revesz, Tamas; Kovacs, Gabor G; van Swieten, John; Takao, Masaki; Hasegawa, Masato; Ghetti, Bernardino; Spillantini, Maria Grazia; Ryskeldi-Falcon, Benjamin; Murzin, Alexey G; Goedert, Michel; Scheres, Sjors H W

Cryo-EM structures of amyloid-β 42 filaments from human brains

人脑中β-淀粉样蛋白42丝的冷冻电镜结构

Yang, Yang; Arseni, Diana; Zhang, Wenjuan; Huang, Melissa; Lövestam, Sofia; Schweighauser, Manuel; Kotecha, Abhay; Murzin, Alexey G; Peak-Chew, Sew Y; Macdonald, Jennifer; Lavenir, Isabelle; Garringer, Holly J; Gelpi, Ellen; Newell, Kathy L; Kovacs, Gabor G; Vidal, Ruben; Ghetti, Bernardino; Ryskeldi-Falcon, Benjamin; Scheres, Sjors H W; Goedert, Michel