The impact of ancestry on performance of type 1 diabetes genetic risk scores: high discrimination performance is maintained in African ancestry populations, but population specific thresholds may improve risk prediction
种族对1型糖尿病遗传风险评分性能的影响:在非洲裔人群中仍保持较高的区分度,但针对特定人群的阈值可能有助于提高风险预测能力。
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doi:10.1101/2025.07.17.25330632
Squires, Steven; Katte, Jean Claude; Dabelea, Dana; Pihoker, Catherine; Divers, Jasmin; Sobngwi, Eugene; Nyirenda, Moffat J; Kreienkamp, Raymond J; Liese, Angela D; Shah, Amy S; Dolan, Lawrence; Reynolds, Kristi; Redondo, Maria J; Hagopian, William; Fatumo, Segun; Dehayem, Mesmin Y; Hattersley, Andrew; Weedon, Michael N; Jones, Angus; Oram, Richard A