BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential
BRK 磷酸化 SMAD4 以进行蛋白酶体降解,并抑制肿瘤抑制因子 FRK 以控制 SNAIL、SLUG 和转移潜能
期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.aaw3113
S Miah, C A S Banks, Y Ogunbolude, E T Bagu, J M Berg, A Saraf, T T Tettey, G Hattem, G Dayebgadoh, C G Kempf, M Sardiu, S Napper, L Florens, K E Lukong, M P Washburn