日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction

两种新型糖皮质激素受体调节基因诱导调节剂的动力学定义机制和作用位置

Madhumita A Pradhan, John A Blackford Jr, Ballachanda N Devaiah, Petria S Thompson, Carson C Chow, Dinah S Singer, S Stoney Simons Jr

Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay

研究资源:通过新的高通量筛选试验鉴定的糖皮质激素受体活性调节剂

John A Blackford Jr, Kyle R Brimacombe, Edward J Dougherty, Madhumita Pradhan, Min Shen, Zhuyin Li, Douglas S Auld, Carson C Chow, Christopher P Austin, S Stoney Simons Jr

Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility

雄性小鼠 Ttll5/stamp 基因(微管酪氨酸连接酶样蛋白 5/SRC-1 和 TIF2 相关调节蛋白基因)破坏导致精子畸形和不育

Geun-Shik Lee, Yuanzheng He, Edward J Dougherty, Maria Jimenez-Movilla, Matteo Avella, Sean Grullon, David S Sharlin, Chunhua Guo, John A Blackford Jr, Smita Awasthi, Zhenhuan Zhang, Stephen P Armstrong, Edra C London, Weiping Chen, Jurrien Dean, S Stoney Simons Jr

PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivation

PA1 蛋白是一种新型竞争性减速剂,可多步抑制糖皮质激素受体介导的转录激活

Zhenhuan Zhang, Yunguang Sun, Young-Wook Cho, Carson C Chow, S Stoney Simons Jr

Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations

辅激活因子 TIF2 的 N 端区域与糖皮质激素受体的内在无序 AF1 结构域的结合伴随着构象重组

Shagufta H Khan, Smita Awasthi, Chunhua Guo, Devrishi Goswami, Jun Ling, Patrick R Griffin, S Stoney Simons Jr, Raj Kumar

Identification of location and kinetically defined mechanism of cofactors and reporter genes in the cascade of steroid-regulated transactivation

类固醇调控转录激活级联中辅因子和报告基因的位置和动力学定义机制的识别

John A Blackford Jr, Chunhua Guo, Rong Zhu, Edward J Dougherty, Carson C Chow, S Stoney Simons Jr

Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction

糖皮质激素受体、辅激活因子 TIF2 和共调节因子 STAMP 的不同区域可修改糖皮质激素介导的基因诱导的不同参数

Smita Awasthi, S Stoney Simons Jr

STAMP alters the growth of transformed and ovarian cancer cells

STAMP 改变转化细胞和卵巢癌细胞的生长

Yuanzheng He, John A Blackford Jr, Elise C Kohn, S Stoney Simons Jr