Multi-chemokine receptor antagonist RAP-103 inhibits opioid-derived respiratory depression, reduces opioid reinforcement and physical dependence, and normalizes opioid-induced dysregulation of mesolimbic chemokine receptors in rats
多趋化因子受体拮抗剂 RAP-103 可抑制阿片类药物引起的呼吸抑制,减少阿片类药物强化和身体依赖,并使阿片类药物引起的大鼠中脑边缘趋化因子受体失调正常化
期刊:Drug and Alcohol Dependence
影响因子:3.9
doi:10.1016/j.drugalcdep.2022.109556
Angela R Bongiovanni, Pingwei Zhao, Saadet Inan, Sonita Wiah, Aryan Shekarabi, Daniel J Farkas, Mia N Watson, Mathieu E Wimmer, Michael R Ruff, Scott M Rawls