Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts
高亲和力 gapmer 反义寡核苷酸的肝毒性是由 RNase H1 依赖的极长前 mRNA 转录本的混杂还原介导的
期刊:Nucleic Acids Research
影响因子:16.6
doi:10.1093/nar/gkv1210
Sebastien A Burel, Christopher E Hart, Patrick Cauntay, Jill Hsiao, Todd Machemer, Melanie Katz, Andy Watt, Huynh-Hoa Bui, Husam Younis, Mahyar Sabripour, Susan M Freier, Gene Hung, Amy Dan, T P Prakash, Punit P Seth, Eric E Swayze, C Frank Bennett, Stanley T Crooke, Scott P Henry