日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mycobacterium tuberculosis MutT4/RppH is an RNA pyrophosphohydrolase that forms condensate-like bodies and impacts mRNA degradation

结核分枝杆菌 MutT4/RppH 是一种 RNA 焦磷酸水解酶,可形成类似凝聚体的结构,并影响 mRNA 的降解。

Cafiero, J Hilario; Xiao, Junpei; Lepori, Irene; Rapiejko, Abigail R; Reddy, Manchi; Ibitoye, Opeyemi I; Roberts, Louis A; Sacchettini, James C; Siegrist, M Sloan; Shell, Scarlet S

SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于 SuFEx 的抗结核化合物不可逆地抑制 Pks13

Krieger, Inna V; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A L; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L; Massoudi, Lisa M; Woolhiser, Lisa K; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R; Kandula, Dilipkumar Reddy; McCabe, Jacob W; Guo, Taijie; Alland, David; Boshoff, Helena I; Schnappinger, Dirk; Robertson, Gregory T; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G; Joseph, Sean B; Love, Melissa S; Sharpless, K Barry; Petrassi, H Michael; Chatterjee, Arnab K; Sacchettini, James C; McNamara, Case W

Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease

艾司洛莫尔-铜疗法改善了两名患有门克斯病的儿童的神经发育。

Godoy-Molina, Elena; Serrano, Natalia L; Jiménez-González, Aquilina; Villaronga, Miquel; Marqués Pérez-Bryan, Rosa M; Varela-Fernández, Rubén; Lotz-Esquivel, Stephanie; Hevia Tuñón, Alba; Trivedi, Prachi P; Horn, Nina; Standing, Joseph F; Mangas-Sanjuan, Víctor; Capdevila, Mercè; Mateos, Aurora; Broun, Denis; Lutsenko, Svetlana; Medina-Rivera, Ines; Artuch, Rafael; Jou, Cristina; Roldán, Mònica; Arango-Sancho, Pedro; Saez-Villafañe, Mónica; Ortiz-de-Urbina, Juan J; Pieras-López, Angela; Duero, Marta; Farré, Rosa; Pijuan, Jordi; Hoenicka, Janet; Sacchettini, James C; Petris, Michael J; Gohil, Vishal M; Palau, Francesc

Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin

分枝杆菌生物素合酶需要辅助蛋白将脱硫生物素转化为生物素

Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger

Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.

将 raltitrexed 从癌细胞胸苷酸合成酶重定向到结核分枝杆菌磷酸泛酰巯基转移酶

Singh Amrita, Ottavi Samantha, Krieger Inna, Planck Kyle, Perkowski Andrew, Kaneko Takushi, Davis Andrew M, Suh Christine, Zhang David, Goullieux Laurent, Alex Alexander, Roubert Christine, Gardner Mark, Preston Marian, Smith Dave M, Ling Yan, Roberts Julia, Cautain Bastien, Upton Anna, Cooper Christopher B, Serbina Natalya, Tanvir Zaid, Mosior John, Ouerfelli Ouathek, Yang Guangli, Gold Ben S, Rhee Kyu Y, Sacchettini James C, Fotouhi Nader, Aubé Jeffrey, Nathan Carl

An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo.

SARS-CoV-2 Mpro 的口服非共价非肽抑制剂可改善体内病毒复制和致病性

Zhou Nian E, Tang Su, Bian Xuelin, Parai Maloy K, Krieger Inna V, Flores Armando, Jaiswal Pradeep K, Bam Radha, Wood Jeremy L, Shi Zhe, Stevens Laura J, Scobey Trevor, Diefenbacher Meghan V, Moreira Fernando R, Baric Thomas J, Acharya Arjun, Shin Joonyoung, Rathi Manish M, Wolff Karen C, Riva Laura, Bakowski Malina A, McNamara Case W, Catanzaro Nicholas J, Graham Rachel L, Schultz David C, Cherry Sara, Kawaoka Yoshihiro, Halfmann Peter J, Baric Ralph S, Denison Mark R, Sheahan Timothy P, Sacchettini James C

Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization

枯草芽孢杆菌YiSK具有草酰乙酸脱羧酶活性,并表现出Mbl依赖性定位。

Tingfeng Guo ,Anthony M Sperber ,Inna V Krieger ,Yi Duan ,Veronica R Chemelewski ,James C Sacchettini ,Jennifer K Herman

Identification of a copper-responsive small molecule inhibitor of uropathogenic Escherichia coli

鉴定一种对铜敏感的泌尿道致病性大肠杆菌小分子抑制剂

Braden S Hanson, Amanuel Hailemariam, Yongjian Yang, Faras Mohamed, George L Donati, Dwight Baker, James Sacchettini, James J Cai, Sargurunathan Subashchandrabose

DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery

DAIKON:一款用于基于靶点的药物发现的数据采集、整合和知识捕获网络应用程序

Rath, Siddhant; Panda, Saswati; Sacchettini, James C; Berthel, Steven J

Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists

蛋白激酶C C1结构域与二酰甘油和其他激动剂相互作用的结构解剖

Katti, Sachin S; Krieger, Inna V; Ann, Jihyae; Lee, Jeewoo; Sacchettini, James C; Igumenova, Tatyana I