日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery.

基于荧光寿命的 FRET 生物传感器用于监测活细胞中 TDP-43 的 N 端结构域依赖性相互作用:一种用于 ALS 和 FTD 药物发现的新方法

Nathan Kochen Noah, Murray Marguerite, Zafari Sophia, Vunnam Nagamani, Liao Elly E, Chen Lihsia, Braun Anthony R, Sachs Jonathan N

Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study

α-突触核蛋白、tau蛋白、FUS蛋白和TDP-43原纤维的亲水腔中存在翻译后修饰位点:一项分子动力学研究

Kochen, Noah Nathan; Seaney, Darren; Vasandani, Vivek; Murray, Marguerite; Braun, Anthony R; Sachs, Jonathan N

Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology

MK886及其衍生物对蛋白酶体的刺激可以挽救tau蛋白诱导的神经突病变

Liao, Elly E; Yang, Mu; Nathan Kochen, Noah; Vunnam, Nagamani; Braun, Anthony R; Ferguson, David M; Sachs, Jonathan N

Zafirlukast Is a Promising Scaffold for Selectively Inhibiting TNFR1 Signaling

扎鲁司特是一种有前景的选择性抑制TNFR1信号通路的支架化合物

Vunnam, Nagamani; Yang, Mu; Lo, Chih Hung; Paulson, Carolyn; Fiers, William D; Huber, Evan; Been, MaryJane; Ferguson, David M; Sachs, Jonathan N

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease

以镰状细胞病药物发现平台为基础,测量镰状血红蛋白原纤维寡聚体的荧光寿命

Vunnam, Nagamani; Hansen, Scott; Williams, Dillon C; Been, MaryJane Olivia; Lo, Chih Hung; Pandey, Anil K; Paulson, Carolyn N; Rohde, John A; Thomas, David D; Sachs, Jonathan N; Wood, David K

The role of wild-type tau in Alzheimer's disease and related tauopathies

野生型tau蛋白在阿尔茨海默病及相关tau蛋白病中的作用

Lo, Chih Hung; Sachs, Jonathan N

Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction

微管蛋白-微管蛋白侧向相互作用的多尺度计算模型

Hemmat, Mahya; Castle, Brian T; Sachs, Jonathan N; Odde, David J

α-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity

α-突触核蛋白独特的长两亲性螺旋结构增强了其膜结合和重塑能力

Braun, Anthony R; Lacy, Michael M; Ducas, Vanessa C; Rhoades, Elizabeth; Sachs, Jonathan N

Polyunsaturated chains in asymmetric lipids disorder raft mixtures and preferentially associate with α-Synuclein

不对称脂质中的多不饱和链会扰乱脂筏混合物,并优先与α-突触核蛋白结合。

Brummel, Benjamin E; Braun, Anthony R; Sachs, Jonathan N

HuR Contributes to TRAIL Resistance by Restricting Death Receptor 4 Expression in Pancreatic Cancer Cells

HuR通过限制胰腺癌细胞中死亡受体4的表达而导致TRAIL耐药性

Romeo, Carmella; Weber, Matthew C; Zarei, Mahsa; DeCicco, Danielle; Chand, Saswati N; Lobo, Angie D; Winter, Jordan M; Sawicki, Janet A; Sachs, Jonathan N; Meisner-Kober, Nicole; Yeo, Charles J; Vadigepalli, Rajanikanth; Tykocinski, Mark L; Brody, Jonathan R