日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice

双重G9a抑制剂和组胺H3受体拮抗剂A-366可改善BTBR T + tf/J小鼠的重复行为和社交行为,并减轻神经炎症。

Hajar, Malak; Jayaprakash, Petrilla; Stark, Holger; Sadek, Bassem

Simultaneous inhibition of cholinesterase and antagonism of histamine H3 receptors alleviates cognitive deficits and mitigates apoptosis in scopolamine-induced amnesia in mice.

同时抑制胆碱酯酶和拮抗组胺 H3 受体可减轻东莨菪碱诱导的小鼠失忆症的认知缺陷和细胞凋亡。

Ebdah Wajd, Thomas Shilu Deepa, Eissa Nermin, Jayaprakash Petrilla, Łażewska Dorota, Kieć-Kononowicz Katarzyna, Sadek Bassem

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

靶向组蛋白H3K9甲基转移酶G9a作为神经精神疾病的潜在治疗策略

Hajar, Malak; Werner, Tobias; Gajic, Mihajlo; Stark, Holger; Sadek, Bassem

The Effects of Novel Thymoquinone-Loaded Nanovesicles as a Promising Avenue to Modulate Autism Associated Dysregulation by Restoring Oxidative Stress in Autism in Mice.

新型百里醌纳米囊泡通过恢复自闭症小鼠的氧化应激来调节自闭症相关失调,是一种有前景的途径

Eissa Nermin, Alwattar Jana K, Jayaprakash Petrilla, Chkier Dana, Ahmed Aala Osama, Ahmed Anum, Rizwan Rameen, Mujeeb Sulthan, Rahal Mohamad, Sadek Bassem

The role of interleukin-37 and interleukin-38 in the development and remission of autism spectrum disorder: a comprehensive review of neuroinflammatory mechanisms and potential therapeutic implications

白细胞介素-37和白细胞介素-38在自闭症谱系障碍的发生发展和缓解中的作用:神经炎症机制及其潜在治疗意义的全面综述

Al Rasbi, Zakeya; Orsud, Hiba; Zoughbor, Sumaya Hasan; Hajar, Malak; Mahboob, Abdulla; Sadek, Bassem

The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder

磷酸二酯酶抑制剂在脆性X综合征和自闭症谱系障碍中的新兴作用

Thomas, Shilu Deepa; Mohammed, Hend Abdulaziz; Hamad, Mohammad I K; Oz, Murat; Statsenko, Yauhen; Sadek, Bassem

Impact of sodium-glucose cotransporter-2 inhibitors on aging biomarkers and plasma ceramide levels in type 2 diabetes: beyond glycemic control.

钠-葡萄糖协同转运蛋白-2抑制剂对2型糖尿病患者衰老生物标志物和血浆神经酰胺水平的影响:超越血糖控制

Shalaby Youssef M, Nakhal Mohammed Moutaz, Afandi Bachar, Al-Zohily Bashar, Majed Lina, Kumar Kukkala Kiran, Emerald Bright Starling, Sadek Bassem, Akour Amal, Akawi Nadia

Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer's Disease, Parkinson's Disease, and Autism Spectrum Disorder

靶向小胶质细胞治疗神经炎症:H3受体拮抗剂作为阿尔茨海默病、帕金森病和自闭症谱系障碍的新型治疗方法

Thomas, Shilu Deepa; Abdalla, Sabna; Eissa, Nermin; Akour, Amal; Jha, Niraj Kumar; Ojha, Shreesh; Sadek, Bassem

Reproductive and fetal toxicity studies of histamine H3 receptor antagonist DL76 used in mice to prevent maximal electroshock-induced seizure

在小鼠中开展组胺H3受体拮抗剂DL76的生殖和胎儿毒性研究,以预防最大电休克诱发的癫痫发作

Bastaki, Salim M; Abdulrazzaq, Yousef M; Zidan, Marwan Abdelrahim; Shafiullah, Mohamed; Alaryani, Saif Ghdayer; Alnuaimi, Fatima Awad; Adeghate, Ernest; Mohsin, Sahar; Akour, Amal; Siwek, Agata; Łażewska, Dorota; Kieć-Kononowicz, Katarzyna; Sadek, Bassem

Alleviation of Autophagic Deficits and Neuroinflammation by Histamine H3 Receptor Antagonist E159 Ameliorates Autism-Related Behaviors in BTBR Mice.

组胺 H3 受体拮抗剂 E159 可缓解自噬缺陷和神经炎症,从而改善 BTBR 小鼠的自闭症相关行为

Thomas Shilu Deepa, Jayaprakash Petrilla, Marwan Nurfirzana Z H J, Aziz Ezzatul A B A, Kuder Kamil, Łażewska Dorota, Kieć-Kononowicz Katarzyna, Sadek Bassem