日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ETV2-ECSCR-mTOR pathways regulate reprogramming to the endothelial lineage.

ETV2-ECSCR-mTOR通路调控向内皮细胞谱系的重编程。

Choi Young Geun, Das Satyabrata, Larson Thijs A, Le Anh Quynh, Nagarajan Usha, Sadek Hesham A, Zhang Jianyi Jay, Garry Mary G, Garry Daniel J

Cardiotropic AAV gene therapy for heart failure: a phase 1 trial

针对心力衰竭的心脏靶向性AAV基因疗法:一项I期试验

Henry, Timothy D; Chung, Eugene S; Alvisi, Monica; Sethna, Ferzin; Murray, David R; Traverse, Jay H; Roessig, Lothar; Roberts, Luke; Reddy, Swarna; Chen, Youjun; Ozkan, Tugba Guven; Webb, Stacy; Mittal, Monika; Ervin, Leigh; Sadek, Hesham; Mikhail, Sheila; Haghighi, Kobra; Jiang, Canwen; Samulski, R Jude; Kranias, Evangelia G; Tretiakova, Anna P; Hajjar, Roger J

Leveraging Transcriptional Readouts as a Platform for Drug Repurposing in Cardiomyopathy

利用转录组读数作为平台进行心肌病药物再利用

Mahmoud, Ahmed I; Sadek, Hesham A

An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models.

FDA 批准的一种药物在结构和表型上纠正了遗传性心肌病模型中的 K210del 突变

Wang Ping, Ahmed Mahmoud Salama, Nguyen Ngoc Uyen Nhi, Menendez-Montes Ivan, Hsu Ching-Cheng, Farag Ayman B, Thet Suwannee, Lam Nicholas T, Wansapura Janaka P, Crossley Eric, Ma Ning, Zhao Shane Rui, Zhang Tiejun, Morimoto Sachio, Singh Rohit, Elhelaly Waleed, Tassin Tara C, Cardoso Alisson C, Williams Noelle S, Pointer Hayley L, Elliott David A, McNamara James W, Watt Kevin I, Porrello Enzo R, Sadayappan Sakthivel, Sadek Hesham A

Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia.

心肌丙酮酸脱氢酶激酶 4 驱动性别特异性的心脏对内毒素血症的反应

Yap John Q, Nikouee Azadeh, Kim Matthew, Cao Quan, Rademacher David J, Lau Jessie E, Arora Ananya, Zou Leila Y, Sun Yuxiao, Szweda Luke, Sadek Hesham, Elliot Sharon, Roos Benjamin, Glassberg Marilyn K, Ji Hong-Long, Gao Xiang, Dong Qunfeng, Zang Qun Sophia

Paracrine IGFBP3 spatially coordinates IGF signaling to induce myocardial regeneration in mice

旁分泌IGFBP3在空间上协调IGF信号传导,从而诱导小鼠心肌再生。

Ali, Shah R; Nguyen, Ngoc Uyen Nhi; Elhelaly, Waleed; Hsu, Ching-Cheng; Li, Shujuan; Menendez-Montes, Ivan; Wang, Zhaoning; Cui, Miao; Elnwasany, Abdallah; Xiao, Feng; Sun, Jisheng; Thet, Suwannee; Lam, Nicholas T; Cardoso, Alisson; Pereira, Ana Helena; Wang, Jinhu; Olson, Eric N; Kinter, Michael T; Szweda, Luke I; Shelton, John; Kimura, Wataru; Sadek, Hesham A

Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms

阿加曲班、格列美脲和雷诺嗪的药物再利用显示出通过多种机制发挥抗SARS-CoV-2活性。

El Sobky, Shereen A; Fawzy, Injie O; Ahmed, Mahmoud S; Ragheb, Manon; Hamad, Merna H M; Bahaaeldin, Rowan; Fahim, Salma A; Saad, Rana; Khalil, Ziad A; Mahmoud, Sara H; Mostafa, Ahmed; Ali, Mohamed A; Sadek, Hesham A; El-Ekiaby, Nada; Abdelaziz, Ahmed I

Transient overexpression of hPKM2 in porcine cardiomyocytes prevents heart failure after myocardial infarction

猪心肌细胞中hPKM2的瞬时过表达可预防心肌梗死后心力衰竭

Sun, Jiacheng; Wu, Yalin; Adjmi, Matthew; Matthews, Rachel C; Kurian, Ann Anu; Żak, Magdalena M; Yoo, Jimeen; Mainkar, Gayatri; Lawless, Hannah; Lu, Yu-An; Soon-Shiong, Patrick; Walcott, Gregory P; Sadek, Hesham A; Zhang, Jianyi; Zangi, Lior

Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility

诱导胞质分裂产生高度增殖的单核心肌细胞,但代价是收缩力下降。

Lam, Nicholas T; Nguyen, Ngoc Uyen Nhi; Elhelaly, Waleed M; Hsu, Ching-Cheng; Menendez-Montes, Ivan; Xiao, Feng; Ali, Shah R; Vo, Nelson; Briard, Nathan; El-Feky, Lobna; Omari, Qamar M; Cardoso, Alisson C; Liu, Yan; Ahmed, Mahmoud Salama; Li, Shujuan; Thet, Suwannee; Xing, Chao; Zangi, Lior; Sadek, Hesham A

Cardiomyocyte DNA Damage Predicts Functional Recovery in Heart Failure Patients

心肌细胞DNA损伤可预测心力衰竭患者的功能恢复

Ali, Shah R; Sadek, Hesham A