日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CAR-adapted PIK3CD base editing enhances T cell anti-tumor potency.

CAR 改造的 PIK3CD 碱基编辑增强了 T 细胞的抗肿瘤效力。

Bucher Philip, Brückner Nadine, Kortendieck Jule, Grimm Melanie, Schleicher Jan T, Bartels Karlotta, Hardy Steffen, Rausch Martina, Wurzer Hannah, Thiemann Meike, May Celina, Mitstorfer Mara, Letzgus Dennis, Quach Julia, Schneider Carolin, Ispan Denis A, Gonzalez-Menendez Irene, Jain Nayan, Ho Yu-Jui, Chen Jiangqing, Sánchez-Rivera Francisco J, Sun Jie, Quintanilla-Martinez Leticia, Trautwein Christoph, Weigelin Bettina, Claassen Manfred, Sadelain Michel, Feucht Judith, Leibold Josef

Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.

抗 uPAR CAR T 细胞可逆转和预防与衰老相关的肠道再生和功能缺陷。

Eskiocak Onur, Gewolb Joseph, Shah Vyom, Rouse James A, Chowdhury Saria, Akyildiz Erdogan O, Fernández-Maestre Inés, Boyer Jacob A, Filliol Aveline, Harris Alexander S, Utama Raditya, Guo Guangran, Castro-Hernández Carolina, Nnuji-John Emmanuella, Chung Charlie, Anderson Arianna, Flowers Sara, Habel Jill, Romesser Paul B, Levine Ross L, Lowe Scott W, Sadelain Michel, Beyaz Semir, Amor Corina

CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53

CD4+ T 细胞淋巴瘤携带嵌合抗原受体整合于 TP53

Perica, Karlo; Jain, Nayan; Scordo, Michael; Patel, Ruchi; Eren, Ozgur Can; Patel, Utsav; Gundem, Gunes; Domenico, Dylan; Mitra, Sneha; Socci, Nicholas D; Everett, John K; Roche, Aoife M; Petrichenko, Angelina; Shah, Gunjan L; Arcila, Maria E; Borsu, Laetitia; Park, Jae H; Horwitz, Steven M; Giralt, Sergio A; Dogan, Ahmet; Leslie, Christina; Papaemmanuil, Elli; Bushman, Frederic D; Usmani, Saad Z; Sadelain, Michel; Mailankody, Sham

Results From First-in-Human Phase I Study of a Novel CD19-1XX Chimeric Antigen Receptor With Calibrated Signaling in Large B-Cell Lymphoma

一项针对新型CD19-1XX嵌合抗原受体的I期临床试验结果显示,该受体在大B细胞淋巴瘤中具有可校准的信号传导功能。

Park, Jae H; Palomba, M Lia; Perica, Karlo; Devlin, Sean M; Shah, Gunjan; Dahi, Parastoo B; Lin, Richard J; Salles, Gilles; Scordo, Michael; Nath, Karthik; Valtis, Yannis K; Lynch, Alec; Cathcart, Elizabeth; Zhang, Honglei; Schoder, Heiko; Leithner, Doris; Liotta, Kelly; Yu, Alina; Stocker, Kelsey; Li, Jia; Dey, Agnish; Sellner, Leopold; Singh, Reshma; Sundaresan, Varsha; Tong, Xin; Zhao, Faye; Mansilla-Soto, Jorge; He, Changhao; Meyerson, Joel; Hosszu, Kinga; McAvoy, Devin; Wang, Xiuyan; Rivière, Isabelle; Sadelain, Michel

CAR-engineered lymphocyte persistence is governed by a FAS ligand-FAS autoregulatory circuit

CAR工程化淋巴细胞的持久性受FAS配体-FAS自身调节回路的调控。

Fei Yi,Tal Cohen,Natalie Zimmerman,Friederike Dündar,Paul Zumbo,Razan Eltilib,Erica J Brophy,Hannah Arkin,Judith Feucht,Michael V Gormally,Christopher S Hackett,Korbinian N Kropp,Inaki Etxeberria,Smita S Chandran,Zeguo Zhao,Winson Cai,Anthony F Daniyan,Jae H Park,Caleb A Lareau,Katharine C Hsu,Michel Sadelain,Doron Betel,Christopher A Klebanoff

Zelig Eshhar (1941–2025): a tribute for a life for immunotherapy

泽利格·埃沙尔(1941–2025):致敬其为免疫疗法做出的毕生贡献

Shrimali, Rajeev; Ahmad, Shamim; Berrong, Zuzana; Okoev, Grigori; Matevosyan, Adelaida; Razavi, Ghazaleh Shoja E; Petit, Robert; Gupta, Seema; Mkrtichyan, Mikayel; Khleif, Samir N; Abken, Hinrich; Allison, James P; Brentjens, Renier; June, Carl H; Lotze, Michael T; Mackall, Crystal; Majzner, Robbie G; Rosenberg, Steven A; Sadelain, Michel; Smith, Eric; Maus, Marcela V

Key considerations for advancing chimeric antigen receptor (CAR) T-cell therapy for systemic lupus erythematosus (SLE): a multi-partner/disciplinary working group perspective

推进嵌合抗原受体(CAR)T细胞疗法治疗系统性红斑狼疮(SLE)的关键考量:多方合作/学科工作组的视角

Hsieh, Elena W Y; Chung, James B; Amin, Afsah; Askanase, Anca D; Bartok, Beatrix; Brunetta, Paul; Carrasco-Alfonso, Marlene J; Coney, Cindy; Cooper, Jennifer C; Dall'Era, Maria; Delev, Nikolay; Eldred, Ann; Furie, Richard A; Garces, Sandra; Groover, Katie; Harrington, Monica; Hogan, Jonathan J; Imperato, Gavin H; Jackson, Meredith; Jackson, Shaun W; Jongco, Artemio M; Karis, Elaine; Koegel, Ashley; König, Maximilian F; Koretzky, Gary; Kumar, Vijay; Morand, Eric; Payne, Aimee S; Popat, Vaishali; Rizvi, Naiyer; Rohan, Patricia; Sadelain, Michel; Schett, Georg; Singh, Aman P; van Vollenhoven, Ronald F; Zack, Debra

Disruption of SUV39H1-Mediated H3K9 Methylation Sustains CAR T-cell Function

SUV39H1 介导的 H3K9 甲基化的破坏可维持 CAR-T 细胞功能

Nayan Jain #, Zeguo Zhao #, Richard P Koche, Chenling Antelope, Yosi Gozlan, Antonino Montalbano, David Brocks, Michael Lopez, Anton Dobrin, Yuzhe Shi, Gertrude Gunset, Theodoros Giavridis, Michel Sadelain

Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies

合成双重共刺激可增强靶向HIT和TCR细胞疗法的效力

Anton Dobrin,Pieter L Lindenbergh,Yuzhe Shi,Karlo Perica,Hongyao Xie,Nayan Jain,Andrew Chow,Jedd D Wolchok,Taha Merghoub,Michel Sadelain,Mohamad Hamieh

Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies

基因敲除黏附配体可减轻同种异体细胞免疫疗法的排斥反应

Quirin Hammer,Karlo Perica,Rina M Mbofung,Hanna van Ooijen,Karen E Martin,Pouria Momayyezi,Erika Varady,Yijia Pan,Mark Jelcic,Brian Groff,Ramzey Abujarour,Silje Z Krokeide,Tom Lee,Alan Williams,Jode P Goodridge,Bahram Valamehr,Björn Önfelt,Michel Sadelain,Karl-Johan Malmberg