日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

ARAF 蛋白激酶通过拮抗其与 RASGAP NF1 的结合来激活 RAS

Wenjing Su, Radha Mukherjee, Rona Yaeger, Jieun Son, Jianing Xu, Na Na, Neilawattie Merna Timaul, Jaclyn Hechtman, Viktoriya Paroder, Mika Lin, Marissa Mattar, Juan Qiu, Qing Chang, Huiyong Zhao, Jonathan Zhang, Megan Little, Yuta Adachi, Sae-Won Han, Barry S Taylor, Hiromichi Ebi, Omar Abdel-Wahab,

Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer

生化和结构分析表明,肿瘤抑制因子神经纤维蛋白(NF1)形成高亲和力二聚体

Mukul Sherekar, Sae-Won Han, Rodolfo Ghirlando, Simon Messing, Matthew Drew, Dana Rabara, Timothy Waybright, Puneet Juneja, Hugh O'Neill, Christopher B Stanley, Debsindhu Bhowmik, Arvind Ramanathan, Sriram Subramaniam, Dwight V Nissley, William Gillette, Frank McCormick, Dominic Esposito

Activation of WNT/β-catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

WNT/β-catenin 信号的激活导致携带 PIK3CA 突变的结肠直肠癌细胞对双重 PI3K/mTOR 抑制剂产生耐药性

Ye-Lim Park, Hwang-Phill Kim, Young-Won Cho, Dong-Wook Min, Seul-Ki Cheon, Yoo Joo Lim, Sang-Hyun Song, Sung Jin Kim, Sae-Won Han, Kyu Joo Park, Tae-You Kim

Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells

巨噬细胞移动抑制因子促进 KRAS 突变结直肠癌细胞对 MEK 阻断产生抵抗作用

Seul-Ki Cheon, Hwang-Phill Kim, Ye-Lim Park, Jee-Eun Jang, Yoojoo Lim, Sang-Hyun Song, Sae-Won Han, Tae-You Kim

FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro

FGFR2 扩增可预测胃癌和结直肠癌对瑞戈非尼的敏感性

Yongjun Cha, Hwang-Phill Kim, Yoojoo Lim, Sae-Won Han, Sang-Hyun Song, Tae-You Kim

A First-Time-in-Human Study of GSK2636771, a Phosphoinositide 3 Kinase Beta-Selective Inhibitor, in Patients with Advanced Solid Tumors

首次对晚期实体瘤患者进行 GSK2636771(一种磷酸肌醇 3 激酶 β 选择性抑制剂)的人体研究

Joaquin Mateo, Gopinath Ganji, Charlotte Lemech, Howard A Burris, Sae-Won Han, Karen Swales, Shaun Decordova, M Phillip DeYoung, Deborah A Smith, Shanker Kalyana-Sundaram, Jiuhua Wu, Monica Motwani, Rakesh Kumar, Jerry M Tolson, Sun Young Rha, Hyun Cheol Chung, Joseph P Eder, Sunil Sharma, Yung-Jue

Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability

在染色体不稳定的人类癌症中,黏连蛋白的减少会破坏复制前复合物的结合,从而破坏高水平基因扩增

Jiyeon Yun, Sang-Hyun Song, Jee-Youn Kang, Jinah Park, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim

Dynamic cohesin-mediated chromatin architecture controls epithelial-mesenchymal plasticity in cancer

动态黏连蛋白介导的染色质结构控制癌症的上皮间质可塑性

Jiyeon Yun, Sang-Hyun Song, Hwang-Phill Kim, Sae-Won Han, Eugene C Yi, Tae-You Kim

Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-Specific Biomarker for Human Gastrointestinal Cancer

LPHN2 的异常表观遗传修饰可作为人类胃肠道癌症的潜在顺铂特异性生物标志物

Mi-Seong Jeon, Sang-Hyun Song, Jiyeon Yun, Jee-Youn Kang, Hwang-Phill Kim, Sae-Won Han, Tae-You Kim

Therapeutic implication of HER2 in advanced biliary tract cancer

HER2 在晚期胆道癌中的治疗意义

Ah-Rong Nam, Ji-Won Kim, Yongjun Cha, Hyerim Ha, Ji Eun Park, Ju-Hee Bang, Mei Hua Jin, Kyung-Hun Lee, Tae-Yong Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang