日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions

全基因组 CRISPR 筛选鉴定出 GRA38 是弓形虫适应富含脂质环境过程中脂质稳态的关键调控因子

Bitew, Mebratu A; Paredes-Santos, Tatiana C; Maru, Parag; Krishnamurthy, Shruthi; Wang, Yifan; Sangaré, Lamba O; Duley, Samuel; Yamaryo-Botté, Yoshiki; Botté, Cyrille Y; Saeij, Jeroen P J

Toxoplasma effector TgWIP hijacks dendritic cell actin and motility via Nck1/Grb2 and the WAVE complex

弓形虫效应蛋白TgWIP通过Nck1/Grb2和WAVE复合物劫持树突状细胞肌动蛋白和运动能力。

Morales, Pavel; Kramer, Daniel A; de Moraes de Siqueira, Caroline; Brown, Abbigale J; Sangaré, Lamba Omar; Chen, Baoyu; Saeij, Jeroen P J

Surface antigen SAG1 mediates Toxoplasma gondii fitness and host cell attachment in IFNγ-stimulated cells

表面抗原SAG1介导弓形虫在IFNγ刺激细胞中的适应性和宿主细胞黏附。

Cohen, Olivia; Maru, Parag; Liang, Qinli; Saeij, Jeroen P J

Fatal Toxoplasma gondii COUG strain infections in southern sea otters (Enhydra lutris nereis): New insight on contributing factors and parasite serotyping.

南方海獭(Enhydra lutris nereis)致命的弓形虫COUG株感染:对致病因素和寄生虫血清分型的新认识

Sinnott Devinn M, Miller Melissa, Arranz-Solís David, Rodriguez Felipe, Saeij Jeroen P J, Batac Francesca, Greenwald Katherine, Young Colleen, Harris Michael D, Gomes Mary, Shapiro Karen

A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions.

全基因组 CRISPR 筛选发现 GRA38 是弓形虫适应富含脂质的环境过程中脂质稳态的关键调节因子

Bitew Mebratu A, Paredes-Santos Tatiana C, Maru Parag, Krishnamurthy Shruthi, Wang Yifan, Sangaré Lamba O, Duley Samuel, Yamaryo-Botté Yoshiki, Botte Cyrille, Saeij Jeroen P J

A parasite odyssey: An RNA virus concealed in Toxoplasma gondii

寄生虫历险记:弓形虫中隐藏的 RNA 病毒

Purav Gupta, Aiden Hiller, Jawad Chowdhury, Declan Lim, Dillon Yee Lim, Jeroen P J Saeij, Artem Babaian, Felipe Rodriguez, Luke Pereira, Alejandro Morales-Tapia

Two Toxoplasma gondii putative pore-forming proteins, GRA47 and GRA72, influence small molecule permeability of the parasitophorous vacuole

两种弓形虫假定的成孔蛋白,GRA47 和 GRA72,影响寄生虫液泡的小分子通透性

Mebratu A Bitew, Pablo S Gaete, Christopher Swale, Parag Maru, Jorge E Contreras, Jeroen P J Saeij

Genome-wide CRISPR screen identifies genes synthetically lethal with GRA17, a nutrient channel encoding gene in Toxoplasma

全基因组 CRISPR 筛选可识别与 GRA17 合成致死的基因,GRA17 是弓形虫中的营养通道编码基因

Tatiana C Paredes-Santos, Mebratu A Bitew, Christopher Swale, Felipe Rodriguez, Shruthi Krishnamurthy, Yifan Wang, Parag Maru, Lamba Omar Sangaré, Jeroen P J Saeij

Late Embryogenesis Abundant Proteins Contribute to the Resistance of Toxoplasma gondii Oocysts against Environmental Stresses

晚期胚胎发生丰富的蛋白质有助于弓形虫卵囊抵抗环境压力

David Arranz-Solís #, David Warschkau #, Benedikt T Fabian, Frank Seeber, Jeroen P J Saeij

CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells.

CRISPR筛选鉴定出弓形虫基因,这些基因决定了寄生虫在γ干扰素刺激的人类细胞中的适应性

Krishnamurthy Shruthi, Maru Parag, Wang Yifan, Bitew Mebratu A, Mukhopadhyay Debanjan, Yamaryo-Botté Yoshiki, Paredes-Santos Tatiana C, Sangaré Lamba O, Swale Christopher, Botté Cyrille Y, Saeij Jeroen P J