Safavi-Hemami Helena相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide

来自MKAVA家族芋螺毒素的Conkazal-M1：一种双功能蛋白酶抑制剂和神经活性肽

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.70580

Hackney, Celeste M; Koch, Thomas Lund; Ryding, Nicklas Lund; Rogalski, Aymeric; Chase, Kevin; Giglio, Matías Leonel; Espino, Samuel S; Acyatan, Zildjian G; Watkins, Maren; Olivera, Baldomero M; Safavi-Hemami, Helena; Teilum, Kaare; Ellgaard, Lars

发表日期：2026

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Ancestral Sequence Reconstruction Provides Insights into the Structural Diversification and Neofunctionalization of T-superfamily Conotoxins in Conus

祖先序列重建揭示了芋螺中T超家族芋螺毒素的结构多样化和新功能化

期刊:Molecular Biology and Evolution

影响因子:5.3

doi:10.1093/molbev/msaf302

Espino, Samuel S; Koch, Thomas Lund; Gajewiak, Joanna; Giglio, Matías L; Watkins, Maren; Safavi-Hemami, Helena; Olivera, Baldomero M

发表日期：2025

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Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold

结构相似性揭示了一个庞大的芋螺毒素家族，其具有双指毒素折叠结构。

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.70333

Khilji, Muhammad Saad; Hackney, Celeste M; Koch, Thomas L; Hone, Arik J; Rogalski, Aymeric; Watkins, Maren; Tun, Jortan; McIntosh, J Michael; Olivera, Baldomero; Safavi-Hemami, Helena; Teilum, Kaare; Ellgaard, Lars

发表日期：2025

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Cone snail venom-inspired somatostatin receptor 4 (SSTR(4)) agonists as new drug leads for peripheral pain

锥螺毒液启发的生长抑素受体4 (SSTR(4))激动剂作为治疗外周疼痛的新药先导化合物

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-26820-5

Bjørn-Yoshimoto, Walden E; Ramiro, Iris Bea L; Koch, Thomas Lund; Engholm, Ebbe; Yeung, Ho Yan; Sørensen, Kasper K; Goddard, Carolyn M; Jensen, Kathrine L; Smith, Nicholas A; Martin, Laurent F; Smith, Brian J; Madsen, Kenneth L; Jensen, Knud J; Patwardhan, Amol; Safavi-Hemami, Helena

发表日期：2025

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Conkazal-M1 from the MKAVA family of conotoxins - a dual-function protease inhibitor and neuroactive peptide

康卡扎尔-M1（Conkazal-M1）属于MKAVA家族芋螺毒素，是一种具有双重功能的蛋白酶抑制剂和神经活性肽。

doi:10.1101/2025.11.05.686841

Hackney, Celeste M; Koch, Thomas Lund; Ryding, Nicklas Lund; Rogalski, Aymeric; Chase, Kevin; Giglio, Matías Leonel; Espino, Samuel S; Acyatan, Zildjian G; Watkins, Maren; Olivera, Baldomero M; Safavi-Hemami, Helena; Teilum, Kaare; Ellgaard, Lars

发表日期：2025

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From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails

从神经肽到毒素：揭示锥螺毒液复杂性的起源

doi:10.1101/2025.09.26.678268

Koch, Thomas Lund; Ferrari, Giada; Sumanam, Sunita B; Salcedo, Paula Flórez; Watkins, Maren; Chase, Kevin; Tooming-Klunderud, Ave; Lluisma, Arturo O; Yanagihara, Angel; Young, Neil D; Olivera, Baldomero M; Undheim, Eivind A B; Safavi-Hemami, Helena

发表日期：2025

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Highlight: Prey-Determined Patterns in Cone Snail Venom Evolution

亮点：锥螺毒液演化中的猎物决定模式

期刊:Molecular Biology and Evolution

影响因子:5.3

doi:10.1093/molbev/msae120

Koch, Thomas Lund; Robinson, Samuel D; Salcedo, Paula Flórez; Chase, Kevin; Biggs, Jason; Fedosov, Alexander E; Yandell, Mark; Olivera, Baldomero M; Safavi-Hemami, Helena; McGrath, Casey

发表日期：2024

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χ-Conotoxins are an Evolutionary Innovation of Mollusk-Hunting Cone Snails as a Counter-Adaptation to Prey Defense

χ-芋螺毒素是捕食软体动物的芋螺为应对猎物防御而进化出的一种创新机制。

期刊:Molecular Biology and Evolution

影响因子:5.3

doi:10.1093/molbev/msae226

Espino, Samuel; Watkins, Maren; Probst, Rodolfo; Koch, Thomas Lund; Chase, Kevin; Imperial, Julita; Robinson, Samuel D; Flórez Salcedo, Paula; Taylor, Dylan; Gajewiak, Joanna; Yandell, Mark; Safavi-Hemami, Helena; Olivera, Baldomero M

发表日期：2024

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Venom-inspired somatostatin receptor 4 (SSTR4) agonists as new drug leads for peripheral pain conditions

受毒液启发而研发的生长抑素受体4 (SSTR4) 激动剂作为治疗外周疼痛疾病的新药先导化合物

doi:10.1101/2024.04.29.591104

Bjørn-Yoshimoto, Walden E; Ramiro, Iris Bea L; Koch, Thomas Lund; Engholm, Ebbe; Yeung, Ho Yan; Sørensen, Kasper K; Goddard, Carolyn M; Jensen, Kathrine L; Smith, Nicholas A; Martin, Laurent F; Smith, Brian J; Madsen, Kenneth L; Jensen, Knud J; Patwardhan, Amol; Safavi-Hemami, Helena

发表日期：2024

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Identification of sodium channel toxins from marine cone snails of the subgenera Textilia and Afonsoconus

从海洋锥螺亚属 Textilia 和 Afonsoconus 中鉴定钠通道毒素

期刊:Cellular and Molecular Life Sciences

影响因子:6.2

doi:10.1007/s00018-023-04935-0

McMahon, Kirsten L; O'Brien, Henrik; Schroeder, Christina I; Deuis, Jennifer R; Venkatachalam, Dhananjeyan; Huang, Di; Green, Brad R; Bandyopadhyay, Pradip K; Li, Qing; Yandell, Mark; Safavi-Hemami, Helena; Olivera, Baldomero M; Vetter, Irina; Robinson, Samuel D

发表日期：2023

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