日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology

重组组织蛋白酶B和L促进α-突触核蛋白的清除,并恢复人类和鼠类α-突触核蛋白病理模型中的溶酶体功能。

Denise Balta # ,Anish Varghese # ,Susy Prieto Huarcaya # ,Alessandro Di Spiezio ,André R A Marques ,Enes Yağız Akdaş ,Doğa Tabakacilar ,Alice Drobny ,Christian Werner ,Wei Xiang ,Rebecca Mächtel ,Jan Philipp Dobert ,Anna Fejtova ,Franziska Richter ,Melanie Küspert ,Philipp Arnold ,Paul Saftig ,Friederike Zunke

MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes

MFSD1 及其附属亚基 GLMP 在溶酶体中充当一般二肽单向转运体

Katharina Esther Julia Jungnickel #, Océane Guelle #, Miharu Iguchi, Wentao Dong, Vadim Kotov, Florian Gabriel, Cécile Debacker, Julien Dairou, Isabelle McCort-Tranchepain, Nouf N Laqtom, Sze Ham Chan, Akika Ejima, Kenji Sato, David Massa López, Paul Saftig, Ahmad Reza Mehdipour, Monther Abu-Remaile

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis

组织蛋白酶 D 基因缺失引发的显著 tau 蛋白病和细胞内 β-淀粉样蛋白积聚:对阿尔茨海默病发病机制的影响

Heather M Terron, Sagar J Parikh, Samer O Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W Dickson, Paul Saftig, Frank M LaFerla, Shelley Lane, Malcolm A Leissring

Non-canonical function of ADAM10 in presynaptic plasticity

ADAM10在突触前可塑性中的非典型功能

Julia Bär ,Tomas Fanutza ,Christopher C Reimann ,Lisa Seipold ,Maja Grohe ,Janike Rabea Bolter ,Flemming Delfs ,Michael Bucher ,Christine E Gee ,Michaela Schweizer ,Paul Saftig ,Marina Mikhaylova

Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis

细胞中主要蛋白酶的消耗揭示了它们对溶酶体蛋白水解的协同作用

Lisa Gallwitz #, Florian Bleibaum #, Matthias Voss #, Michaela Schweizer, Katharina Spengler, Dominic Winter, Frederic Zöphel, Stephan Müller, Stefan Lichtenthaler, Markus Damme, Paul Saftig

Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression

抑制 BACE1 会影响其 Aβ 生成和降解活性,并在 BACE1 高水平表达时增加 Aβ42 和 Aβ40 水平

Irem Ulku, Rocher Leung, Fritz Herre, Lina Walther, Adeola Shobo, Paul Saftig, Mark A Hancock, Filip Liebsch, Gerhard Multhaup

LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development

LAMP2 调节胸腺上皮细胞自噬和胸腺基质依赖性 CD4 T 细胞发育

Pedro M Rodrigues, Laura G Sousa, Chiara Perrod, Ana R Maceiras, Pedro Ferreirinha, Rita Pombinho, Gema Romera-Cárdenas, María Gomez-Lazaro, Meryem Senkara, Jelena Pistolic, Didier Cabanes, Ludger Klein, Paul Saftig, Nuno L Alves

Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor

溶酶体靶向多功能脂质探针揭示甾醇转运蛋白NPC1是鞘氨醇的相互作用蛋白

Altuzar, Janathan; Notbohm, Judith; Stein, Frank; Haberkant, Per; Hempelmann, Pia; Heybrock, Saskia; Worsch, Jutta; Saftig, Paul; Höglinger, Doris

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes

小GTPases的连续功能引导HOPS介导的晚期内体和溶酶体的束缚

Ariane Schleinitz, Lara-Alina Pöttgen, Tal Keren-Kaplan, Jing Pu, Paul Saftig, Juan S Bonifacino, Albert Haas, Andreas Jeschke

A systematic review and narrative synthesis of physical activity referral schemes' components

对体育活动转介计划各组成部分进行系统性回顾和叙述性综合分析

Mino, Eriselda; Hanson, Coral L; Naber, Inga; Weissenfels, Anja; McHale, Sheona; Saftig, Jane; Klamroth, Sarah; Gelius, Peter; Abu-Omar, Karim; Whiting, Stephen; Wickramasinghe, Kremlin; Galea, Gauden; Pfeifer, Klaus; Geidl, Wolfgang