日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype

空气污染与神经炎症标志物、突触功能障碍和阿尔茨海默病核心病理之间的关联因APOE基因型而异

Kimura, Kana; Driscoll, Ira; Cook, Noah; Shahzad, Sonia; Betthauser, Tobey J; Johnson, Sterling C; Asthana, Sanjay; Gallagher, Catherine L; Hermann, Bruce P; Sager, Mark A; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia M; Kollmorgen, Gwendlyn; Okonkwo, Ozioma C

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

一项包含56241名个体的多族裔全基因组荟萃分析,发现了已知的和新的跨人群及族裔特异性关联,这些关联被认为是阿尔茨海默病的新风险位点。

Rajabli, Farid; Benchek, Penelope; Tosto, Giuseppe; Kushch, Nicholas; Sha, Jin; Bazemore, Katrina; Zhu, Congcong; Lee, Wan-Ping; Haut, Jacob; Hamilton-Nelson, Kara L; Wheeler, Nicholas R; Zhao, Yi; Farrell, John J; Grunin, Michelle A; Leung, Yuk Yee; Kuksa, Pavel P; Li, Donghe; da Fonseca, Eder Lucio; Mez, Jesse B; Palmer, Ellen L; Pillai, Jagan; Sherva, Richard M; Song, Yeunjoo E; Zhang, Xiaoling; Ikeuchi, Takeshi; Iqbal, Taha; Pathak, Omkar; Valladares, Otto; Reyes-Dumeyer, Dolly; Kuzma, Amanda B; Abner, Erin; Adams, Larry D; Adams, Perrie M; Aguirre, Alyssa; Albert, Marilyn S; Albin, Roger L; Allen, Mariet; Alvarez, Lisa; Apostolova, Liana G; Arnold, Steven E; Asthana, Sanjay; Atwood, Craig S; Auerbach, Sanford; Ayres, Gayle; Baldwin, Clinton T; Barber, Robert C; Barnes, Lisa L; Barral, Sandra; Beach, Thomas G; Becker, James T; Beecham, Gary W; Beekly, Duane; Benitez, Bruno A; Bennett, David; Bertelson, John; Bird, Thomas D; Blacker, Deborah; Boeve, Bradley F; Bowen, James D; Boxer, Adam; Brewer, James; Burke, James R; Burns, Jeffrey M; Buxbaum, Joseph D; Cairns, Nigel J; Cantwell, Laura B; Cao, Chuanhai; Carlson, Christopher S; Carlsson, Cynthia M; Carney, Regina M; Carrasquillo, Minerva M; Chasse, Scott; Chesselet, Marie-Francoise; Chin, Nathaniel A; Chui, Helena C; Chung, Jaeyoon; Craft, Suzanne; Crane, Paul K; Cribbs, David H; Crocco, Elizabeth A; Cruchaga, Carlos; Cuccaro, Michael L; Cullum, Munro; Darby, Eveleen; Davis, Barbara; De Jager, Philip L; DeCarli, Charles; DeToledo, John; Dick, Malcolm; Dickson, Dennis W; Dombroski, Beth A; Doody, Rachelle S; Duara, Ranjan; Ertekin-Taner, NIlüfer; Evans, Denis A; Faber, Kelley M; Fairchild, Thomas J; Fallon, Kenneth B; Fardo, David W; Farlow, Martin R; Fernandez-Hernandez, Victoria; Ferris, Steven; Friedland, Robert P; Foroud, Tatiana M; Frosch, Matthew P; Fulton-Howard, Brian; Galasko, Douglas R; Gamboa, Adriana; Gearing, Marla; Geschwind, Daniel H; Ghetti, Bernardino; Gilbert, John R; Go, Rodney C P; Goate, Alison M; Grabowski, Thomas J; Graff-Radford, Neill R; Green, Robert C; Growdon, John H; Hakonarson, Hakon; Hall, James; Hamilton, Ronald L; Harari, Oscar; Hardy, John; Harrell, Lindy E; Head, Elizabeth; Henderson, Victor W; Hernandez, Michelle; Hohman, Timothy; Honig, Lawrence S; Huebinger, Ryan M; Huentelman, Matthew J; Hulette, Christine M; Hyman, Bradley T; Hynan, Linda S; Ibanez, Laura; Jarvik, Gail P; Jayadev, Suman; Jin, Lee-Way; Johnson, Kim; Johnson, Leigh; Kamboh, M Ilyas; Karydas, Anna M; Katz, Mindy J; Kauwe, John S; Kaye, Jeffrey A; Keene, C Dirk; Khaleeq, Aisha; Kikuchi, Masataka; Kim, Ronald; Knebl, Janice; Kowall, Neil W; Kramer, Joel H; Kukull, Walter A; LaFerla, Frank M; Lah, James J; Larson, Eric B; Lerner, Alan; Leverenz, James B; Levey, Allan I; Lieberman, Andrew P; Lipton, Richard B; Logue, Mark; Lopez, Oscar L; Lunetta, Kathryn L; Lyketsos, Constantine G; Mains, Douglas; Margaret, Flanagan E; Marson, Daniel C; Martin, Eden Rr; Martiniuk, Frank; Mash, Deborah C; Masliah, Eliezer; Massman, Paul; Masurkar, Arjun; McCormick, Wayne C; McCurry, Susan M; McDavid, Andrew N; McDonough, Stefan; McKee, Ann C; Mesulam, Marsel; Miller, Bruce L; Miller, Carol A; Miller, Joshua W; Montine, Thomas J; Monuki, Edwin S; Morris, John C; Mukherjee, Shubhabrata; Myers, Amanda J; Nguyen, Trung; Obisesan, Thomas; O'Bryant, Sid; Olichney, John M; Ory, Marcia; Palmer, Raymond; Parisi, Joseph E; Paulson, Henry L; Pavlik, Valory; Paydarfar, David; Perez, Victoria; Peskind, Elaine; Petersen, Ronald C; Petrovitch, Helen; Pierce, Aimee; Polk, Marsha; Poon, Wayne W; Potter, Huntington; Qu, Liming; Quiceno, Mary; Quinn, Joseph F; Raj, Ashok; Raskind, Murray; Reiman, Eric M; Reisberg, Barry; Reisch, Joan S; Ringman, John M; Roberson, Erik D; Rodriguear, Monica; Rogaeva, Ekaterina; Rosen, Howard J; Rosenberg, Roger N; Royall, Donald R; Sabbagh, Marwan; Sadovnick, A Dessa; Sager, Mark A; Sano, Mary; Saykin, Andrew J; Schneider, Julie A; Schneider, Lon S; Seeley, William W; Slifer, Susan H; Small, Scott; Smith, Amanda G; Smith, Janet P; Sonnen, Joshua A; Spina, Salvatore; George-Hyslop, Peter St; Starks, Takiyah D; Stern, Robert A; Stevens, Alan B; Strittmatter, Stephen M; Sultzer, David; Swerdlow, Russell H; Tanzi, Rudolph E; Tilson, Jeffrey L; Trojanowski, John Q; Troncoso, Juan C; Tsolaki, Magda; Tsuang, Debby W; Van Deerlin, Vivianna M; van Eldik, Linda J; Vance, Jeffery M; Vardarajan, Badri N; Vassar, Robert; Vinters, Harry V; Vonsattel, Jean-Paul; Weintraub, Sandra; Welsh-Bohmer, Kathleen A; Whitehead, Patrice L; Wijsman, Ellen M; Wilhelmsen, Kirk C; Williams, Benjamin; Williamson, Jennifer; Wilms, Henrik; Wingo, Thomas S; Wisniewski, Thomas; Woltjer, Randall L; Woon, Martin; Wright, Clinton B; Wu, Chuang-Kuo; Younkin, Steven G; Yu, Chang-En; Yu, Lei; Zhu, Xiongwei; Kunkle, Brian W; Bush, William S; Miyashita, Akinori; Byrd, Goldie S; Wang, Li-San; Farrer, Lindsay A; Haines, Jonathan L; Mayeux, Richard; Pericak-Vance, Margaret A; Schellenberg, Gerard D; Jun, Gyungah R; Reitz, Christiane; Naj, Adam C

The impact of estimated cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline

评估心肺适能对阿尔茨海默病生物标志物的影响及其与认知衰退的关系

Paulsen, Adam J; Driscoll, Ira; Breidenbach, Brianne M; Glittenberg, Matthew; Lose, Sarah R; Ma, Yue; Sager, Mark A; Carlsson, Cynthia M; Gallagher, Catherine L; Hermann, Bruce P; Blennow, Kaj; Zetterberg, Henrik; Asthana, Sanjay; Johnson, Sterling C; Betthauser, Tobey J; Christian, Bradley T; Cook, Dane B; Okonkwo, Ozioma C

More fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles

体能较好的KL-VS杂合子具有更有利的AD相关生物标志物谱。

Jarchow, Mackenzie; Driscoll, Ira; Breidenbach, Brianne M; Cook, Noah; Gallagher, Catherine L; Johnson, Sterling C; Asthana, Sanjay; Hermann, Bruce P; Sager, Mark A; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia M; Kollmorgen, Gwendlyn; Quijano-Rubio, Clara; Cook, Dane B; Dubal, Dena B; Okonkwo, Ozioma C

Older more fit KL-VS heterozygotes have more favorable AD-relevant biomarker profiles

年龄较大、身体状况较好的KL-VS杂合子具有更有利的AD相关生物标志物谱

Jarchow, Mackenzie; Driscoll, Ira; Breidenbach, Brianne M; Cook, Noah; Gallagher, Catherine L; Johnson, Sterling C; Asthana, Sanjay; Hermann, Bruce P; Sager, Mark A; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia M; Kollmorgen, Gwendlyn; Quijano-Rubio, Clara; Cook, Dane B; Dubal, Dena B; Okonkwo, Ozioma C

Healthy diet and cognition in Finnish adults: a comparison of Mediterranean, Nordic, and MIND diets

芬兰成年人的健康饮食与认知能力:地中海饮食、北欧饮食和MIND饮食的比较

Schultz, Stephanie A; Boots, Elizabeth A; Almeida, Rodrigo P; Oh, Jennifer M; Einerson, Jean; Korcarz, Claudia E; Edwards, Dorothy F; Koscik, Rebecca L; Dowling, Maritza N; Gallagher, Catherine L; Bendlin, Barbara B; Christian, Bradley T; Zetterberg, Henrik; Blennow, Kaj; Carlsson, Cynthia M; Asthana, Sanjay; Hermann, Bruce P; Sager, Mark A; Johnson, Sterling C; Stein, James H; Okonkwo, Ozioma C; Lehtisalo, J; Kaartinen, NE; Hänninen, T; Jääskeläinen, T; Koskinen, S; Männistö, S

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults

KLOTHO KL-VS杂合性与老年认知功能正常成年人中年龄相关性神经炎症、神经退行性变和突触功能障碍的减轻有关

Driscoll, Ira Frahmand; Lose, Sarah; Ma, Yue; Bendlin, Barbara B; Gallagher, Catherine; Johnson, Sterling C; Asthana, Sanjay; Hermann, Bruce; Sager, Mark A; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia; Kollmorgen, Gwendlyn; Quijano-Rubio, Clara; Dubal, Dena; Okonkwo, Ozioma C

Cardiorespiratory Fitness Modifies the Association of Cerebral Pulsatility on CSF Biomarkers Related to Neurodegeneration, Synaptic Dysfunction, and Neuroinflammation

心肺功能会影响脑搏动与脑脊液生物标志物(与神经退行性变、突触功能障碍和神经炎症相关)之间的关联

Hu, Jiyun; Li, Wenchao; Xie, Shucai; Liao, Ya; Chen, Tao; Wang, Xinrun; Xia, Weiping; Huang, Fang; Qian, Zhaoxin; Zhang, Lina; Akinyemi, Tolulope O; Benedet, Andrea L; Olalusi, Oladotun V; Ogunde, Gabriel O; Yaria, Joseph O; Cadmus, Eniola O; Popoola, Femi O; Ogunronbi, Mayowa; Olujobi, Dorcas; Famuyiwa, Olaoluwa; Akinyemi, Joshua O; Owolabi, Mayowa O; Romero‐Ortuno, Roman; Ogunniyi, Adesola; Pericak‐Vance, Margaret; Kalaria, Raj; Udeh‐Momoh, Chinedu T; Zetterberg, Henrik; Akinyemi, Rufus O; Brach, Talia L; Breidenbach, Brianne M; Glittenberg, Matthew P; Symanski, Leah E; Naren, Tarun; Driscoll, Ira; Lose, Sarah R; Gallagher, Catherine L; Johnson, Sterling C; Asthana, Sanjay; Betthauser, Tobey J; Rivera‐Rivera, Leonardo A; Hermann, Bruce P; Sager, Mark A; Blennow, Kaj; Zetterberg, Henrik; Carlsson, Cynthia M; Kollmorgen, Gwendlyn; Quijano‐Rubio, Clara; Cook, Dane B; Wieben, Oliver; Okonkwo, Ozioma C

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease

在阿尔茨海默病风险人群中,脑脊液中循环Klotho蛋白水平高于血清,且在KLOTHO杂合子中水平升高。

Gaitán, Julian M; Asthana, Sanjay; Carlsson, Cynthia M; Engelman, Corinne D; Johnson, Sterling C; Sager, Mark A; Wang, Dan; Dubal, Dena B; Okonkwo, Ozioma C

Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer's disease

利用先进的扩散磁共振成像技术测量健康老年人(有患阿尔茨海默病风险)白质微结构的年龄相关差异

Motovylyak, Alice; Vogt, Nicholas M; Adluru, Nagesh; Ma, Yue; Wang, Rui; Oh, Jennifer M; Kecskemeti, Steven R; Alexander, Andrew L; Dean, Douglas C; Gallagher, Catherine L; Sager, Mark A; Hermann, Bruce P; Rowley, Howard A; Johnson, Sterling C; Asthana, Sanjay; Bendlin, Barbara B; Okonkwo, Ozioma C