CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer.
CHK1 抑制剂通过靶向 PARG 诱导 PARylation，导致过度复制和代谢压力，从而克服卵巢癌的化疗耐药性
期刊:Cell Death Discovery
影响因子:7
doi:10.1038/s41420-024-02040-0
Acharya Ganesh, Mani Chinnadurai, Sah Naresh, Saamarthy Karunakar, Young Robert, Reedy Mark B, Sobol Robert W, Palle Komaraiah
