日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Development of a Scalable Synthetic Route to (1R,5R)-2,2-Dimethoxybicyclo[3.1.0]hexan-3-one: An Important Intermediate in the Synthesis of Lenacapavir

开发一种可扩展的合成路线来合成(1R,5R)-2,2-二甲氧基双环[3.1.0]己-3-酮：Lenacapavir合成中的重要中间体

期刊:Organic Process Research & Development
影响因子:3.5
doi:10.1021/acs.oprd.4c00527
Nunes De Souza, Aline; Sakkani, Nagaraju; Guthrie, Daryl; Sahani, Rajkumar Lalji; Saathoff, John M; Hochstetler, Samuel R; Burns, Justina M; Ahmad, Saeed; Laidlaw, G Michael; Gupton, B Frank; Klumpp, Douglas A; Jin, Limei
发表日期：2025
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Synthetic Process Development of (R)-(+)-1,2-Epoxy-5-hexene: An Important Chiral Building Block

(R)-(+)-1,2-环氧-5-己烯的合成工艺开发：一种重要的手性砌块

期刊:Organic Process Research & Development
影响因子:3.5
doi:10.1021/acs.oprd.4c00101
Guthrie, Daryl; Saathoff, John M; Sahani, Rajkumar Lalji; Nunes De Souza, Aline; Cook, Daniel W; Hochstetler, Samuel R; Burns, Justina M; Moazeni-Pourasil, Roudabeh Sadat; Wierzbicki, Janie; Ahmad, Saeed; Laidlaw, G Michael; Gupton, B Frank; Shanahan, Charles S; Klumpp, Douglas A; Jin, Limei
发表日期：2024
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Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability.

靶向 HIV-1 衣壳蛋白的新型 PF74 样小分子：效力和代谢稳定性的平衡

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2020.07.016
Wang Lei, Casey Mary C, Vernekar Sanjeev Kumar V, Sahani Rajkumar Lalji, Kirby Karen A, Du Haijuan, Zhang Huanchun, Tedbury Philip R, Xie Jiashu, Sarafianos Stefan G, Wang Zhengqiang
代谢
发表日期：2021
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Potency and metabolic stability: a molecular hybrid case in the design of novel PF74-like small molecules targeting HIV-1 capsid protein.

效力和代谢稳定性：针对 HIV-1 衣壳蛋白的新型 PF74 样小分子设计中的分子混合案例

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d1md00292a
Sahani Rajkumar Lalji, Akther Thamina, Cilento Maria E, Castaner Andres Emanuelli, Zhang Huanchun, Kirby Karen A, Xie Jiashu, Sarafianos Stefan G, Wang Zhengqiang
代谢
发表日期：2021
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Design, Synthesis and Characterization of HIV-1 CA-Targeting Small Molecules: Conformational Restriction of PF74

HIV-1 CA靶向小分子的设计、合成和表征：PF74的构象限制

期刊:Viruses-Basel
影响因子:3.5
doi:10.3390/v13030479
Sahani, Rajkumar Lalji; Diana-Rivero, Raquel; Vernekar, Sanjeev Kumar V; Wang, Lei; Du, Haijuan; Zhang, Huanchun; Castaner, Andres Emanuelli; Casey, Mary C; Kirby, Karen A; Tedbury, Philip R; Xie, Jiashu; Sarafianos, Stefan G; Wang, Zhengqiang
HIV
微生物学
发表日期：2021
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Chemical profiling of HIV-1 capsid-targeting antiviral PF74

HIV-1衣壳靶向抗病毒药物PF74的化学成分分析

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2020.112427
Wang, Lei; Casey, Mary C; Vernekar, Sanjeev Kumar V; Do, Ha T; Sahani, Rajkumar Lalji; Kirby, Karen A; Du, Haijuan; Hachiya, Atsuko; Zhang, Huanchun; Tedbury, Philip R; Xie, Jiashu; Sarafianos, Stefan G; Wang, Zhengqiang
HIV
微生物学
发表日期：2020
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Novel HIV-1 capsid-targeting small molecules of the PF74 binding site

针对HIV-1衣壳PF74结合位点的新型小分子

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2020.112626
Wang, Lei; Casey, Mary C; Vernekar, Sanjeev Kumar V; Sahani, Rajkumar Lalji; Kankanala, Jayakanth; Kirby, Karen A; Du, Haijuan; Hachiya, Atsuko; Zhang, Huanchun; Tedbury, Philip R; Xie, Jiashu; Sarafianos, Stefan G; Wang, Zhengqiang
HIV
微生物学
发表日期：2020
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Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

开发结构新颖且代谢稳定的HIV-1衣壳靶向小分子

期刊:Viruses-Basel
影响因子:3.5
doi:10.3390/v12040452
Vernekar, Sanjeev Kumar V; Sahani, Rajkumar Lalji; Casey, Mary C; Kankanala, Jayakanth; Wang, Lei; Kirby, Karen A; Du, Haijuan; Zhang, Huanchun; Tedbury, Philip R; Xie, Jiashu; Sarafianos, Stefan G; Wang, Zhengqiang
代谢
HIV
微生物学
发表日期：2020
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