日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Porphyrin overdrive rewires cancer cell metabolism

卟啉过量激活可重塑癌细胞代谢

Swamy R Adapa ,Gregory A Hunter ,Narmin E Amin ,Christopher Marinescu ,Andrew Borsky ,Elizabeth M Sagatys ,Said M Sebti ,Gary W Reuther ,Gloria C Ferreira ,Rays Hy Jiang

Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers

新型突变 KRAS 成瘾特征可预测肺癌和胰腺癌对 ERBB 和 MEK 抑制剂联合治疗的反应

Katarzyna M Tyc, Aslamuzzaman Kazi, Alok Ranjan, Rui Wang, Said M Sebti

Inhibiting Isoprenylation Suppresses FcεRI-Mediated Mast Cell Function and Allergic Inflammation

抑制异戊二烯化可抑制FcεRI介导的肥大细胞功能和过敏性炎症

Jordan M Dailey ,Sydney A Kee ,Anuj Tharakan ,Aslamuzzaman Kazi ,Jason R Burchett ,Elizabeth Motunrayo Kolawole ,William Boyd Ballance ,Aditya Kotha ,Quang T Le ,Lawrence B Schwartz ,David B Straus ,Rebecca K Martin ,Said M Sebti ,John J Ryan

Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells

Chk1 抑制可有效阻断人类多发性骨髓瘤细胞中的 STAT3 酪氨酸 705 磷酸化、DNA 结合活性和下游靶标的激活

Liang Zhou, Xinyan Pei, Yu Zhang, Yanxia Ning, Lin Li, Xiaoyan Hu, Sri Lakshmi Chalasani, Kanika Sharma, Jewel Nkwocha, Jonathan Yu, Dipankar Bandyopadhyay, Said M Sebti, Steven Grant

CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

CD28 共刺激结构域靶向突变增强嵌合抗原受体 T 细胞功能

Justin C Boucher, Gongbo Li, Hiroshi Kotani, Maria L Cabral, Dylan Morrissey, Sae Bom Lee, Kristen Spitler, Nolan J Beatty, Estelle V Cervantes, Bishwas Shrestha, Bin Yu, Aslamuzzaman Kazi, Xuefeng Wang, Said M Sebti, Marco L Davila

The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells

GTPase KRAS 通过激活癌细胞中 NRF2 调节的抗氧化防御系统来抑制 p53 肿瘤抑制因子

Hua Yang, Shengyan Xiang, Aslamuzzaman Kazi, Said M Sebti

Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors

法呢基和香叶基香叶基转移酶双重抑制剂可抑制由 KRAS 基因突变引发的患者源性胰腺肿瘤

Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Muhammad Ayaz, Steven Fletcher, Christopher Cummings, Harshani R Lawrence, Francisca Beato, Ya'an Kang, Michael P Kim, Andrea Delitto, Patrick W Underwood, Jason B Fleming, Jose G Trevino, Andrew D Hamilton, Said M Sebti

Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs

维生素 E δ-生育三烯酚通过蛋白酶体介导的 c-FLIPs 下调使人类胰腺癌细胞对 TRAIL 诱导的细胞凋亡敏感

Rony A Francois #, Anying Zhang #, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K Batra, Domenico Coppola, Said M Sebti, Mokenge P Malafa

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth

PTEN拮抗FBXL2,促进IP3R3和Ca2+介导的细胞凋亡,从而限制肿瘤生长。

Shafi Kuchay ,Carlotta Giorgi ,Daniele Simoneschi ,Julia Pagan ,Sonia Missiroli ,Anita Saraf ,Laurence Florens ,Michael P Washburn ,Ana Collazo-Lorduy ,Mireia Castillo-Martin ,Carlos Cordon-Cardo ,Said M Sebti ,Paolo Pinton ,Michele Pagano

Combined HMG-COA reductase and prenylation inhibition in treatment of CCM

联合使用 HMG-COA 还原酶和异戊烯化抑制治疗 CCM

Sayoko Nishimura, Ketu Mishra-Gorur, JinSeok Park, Yulia V Surovtseva, Said M Sebti, Andre Levchenko, Angeliki Louvi, Murat Gunel