IL-12-secreting CAR-T cells reprogram the tumor microenvironment and improve efficacy against heterogeneous models of glioblastoma.
分泌IL-12的CAR-T细胞可重编程肿瘤微环境,提高对异质性胶质母细胞瘤模型的疗效。
期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2025-012532
Shen Steven, Mohan Aditya A, Hotchkiss Kelly M, Cook Sarah, Patel Kisha, Moelker Eliese, Puviindran Bhairavy, Gonzalez Ariel T, Zaidi Saif, Spellicy Samantha, Schwartz Adam, Suryadevara Carter, Wilkinson Daniel, Ayasoufi Katayoun, Fecci Peter E, Sanchez-Perez Luis, Sampson John, Patel Anoop
肿瘤
T细胞
肿瘤免疫
T细胞
细胞生物学
肿瘤微环境
免疫/内分泌